Diagnostic Accuracy of Cerebrospinal Fluid Adenosine Deaminase Activity in Tuberculous Meningitis

Title: Diagnostic Accuracy of Cerebrospinal Fluid Adenosine Deaminase Activity in Tuberculous Meningitis

Authors: Dr Radhika Krishnaswamy, Priyadharshini K

DOI: http://dx.doi.org/10.18535/jmscr/v4i9.43

Abstract

References

Corresponding Author

Abstract

Tuberculous meningitis remains an important cause of morbidity and mortality in developing countries like India.It often poses diagnostic problem to the clinicians, and the prognosis of the disease depends on the stage at which the treatment is started. Adenosine deaminase (ADA) activity is a quick noninvasive method to diagnose of tuberculous meningitis.(TBM) compared to other methods which are less diagnostic and time consuming. The present study was conducted to evaluate the diagnostic accuracy of a cutoff point of 8IU/L of ADA activity in the cerebrospinal fluid for the diagnosis of tuberculous meningitis(TBM) .CSF from 85 patients suffering from meningitis and other CNS disorders were collected and ADA activity was determined..There was a significant elevation of ADA in TBM patients compared to Non TBM group which consisted of bacterial meningitis, encephalitis and other cases. The study showed a sensitivity, specificity and accuracy of of 95% ,92%and 92% respectively In conclusion ,the results of the present study confirms that CSFADA activity, withthe cut off value of 8 IU/L is found to have good sensitivity, specificity and accuracy and can be a good diagnostic marker for tuberculous meningitis. It is simple, inexpensive, takes less time to perform and thus can be considered as a rapid diagnostic test for tuberculous meningitis.

Key words: ADA,CSF, tuberculous meningitis, T lymphocytes.

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