Title: Evaluation of Serum Level of Apelin in Patients with Atopic Dermatitis
Authors: Prof. Dr Magdi Abd Aziz Ragab, Prof. Dr Magdi Mamdoh El Bardini, Prof. Dr Tarek Mahmoud Hussein, Sabrin Ebrahim Ahmed Ebrahim
DOI: http://dx.doi.org/10.18535/jmscr/v4i9.19
Background: Atopic eczema (AE), also known as atopic dermatitis, is a chronic inflammatory skin disorder, characterized by cutaneous dryness, intense itching, scratching, skin damage, and secondary infections. Its cause remains unknown, although it is probably a combination of genetic, environmental, and immunologic factors. The prevalence of AE has risen substantially in many countries in recent decades, and this increase has been attributed mainly to changes in lifestyle, nutrition, and environmental factors. Aim of the work: The aim of the work was toevaluate the serum level of Apelin in patients with atopic dermatitis and its correlation with disease severity in presence or absence of obesity. Subjects: The present study included twenty patients with atopic dermatitis, twenty patients with atopic dermatitis and obesity, twenty patients with obesity only and twenty age and sex matched normal control subjects. Venous blood samples were taken for measurement of serum concentration of apelin and IgE. Results: The results presented in our study demonstrate that a statistically significant difference in the level of apelin and statistically non-significant difference in level of IgE between four studied groups. Conclusion: Our findings provided that apelin serum level increased with obesity and decreased with AD, with no correlation with both BMI and SCORAD which suggesting negative relation between apelin and severity of both diseases, also suggesting no association between severity of both diseases through our finding of no correlation between BMI and SCORAD. Keywords: AD, apelin, IgE.
Abstract
