A Comparative Study of Ondansetron versus Ondansetron with Dexamethasone in Prevention of Postoperative Nausea and Vomiting (PONV) in Patients Undergoing Modified Radical Mastectomy with Axillary Node Dissection Under General Anaesthesia

Title: A Comparative Study of Ondansetron versus Ondansetron with Dexamethasone in Prevention of Postoperative Nausea and Vomiting (PONV) in Patients Undergoing Modified Radical Mastectomy with Axillary Node Dissection Under General Anaesthesia

Authors: Sahoo Alok Kumar, Das Prajnyananda, Danta Sachidananda

DOI: http://dx.doi.org/10.18535/jmscr/v4i9.11

Abstract

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Abstract

Modified radical mastectomy surgeries used to have high incidence of nausea and vomiting. Ondansetron and Dexamethasone both used to prevent postoperative nausea and vomiting .We evaluated the efficacy of Dexamethasone in combination with ondansetron verses ondensetron alone.

Methods- in a prospective double blind study of 80 patients scheduled for MRM with axillary node clearance taken in to consideration. Group O (n=40) given ondensetron 8mg alone and group D(n=40) given ondensetron 8mg with Dexamethasone 8mg. all patient have standard methods of anaesthesia and mastectomy. Episodes of PONV noted with standard 4 point scale.

Observation and Results- demographic profile in both group are comparable. The PONV lower in Dexamethasone group in first 6hr period( 17.5% vs 40% p<0.05%).

In 6-12 hr, the the PONV in Dexamethasone group is still lower (7.5% vs 20% p>0.05) but it is not statistically significant. In 12to 24 hr 100% patient in Dexamethasone group is completely free of PONV. There is minimal adverse effect of both of these drugs.

Conclusion- Preoperative intravenous Dexamethasone (8 mg) in combination with ondansetron can significantly reduce the incidence of PONV in patients undergoing mastectomy with axillary dissection for breast cancer.

Keywords PONV, MRM, Dexamethasone , ondensetron.

References

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