Title: Metastatic Skin Nodules -Is It Pointing Towards Aggressive Tumor Biology?
Authors: Dr Padhi Sanjukta MD, Dr Meher Papuji MD, Dr Pujari Lincoln MD
DOI: https://dx.doi.org/10.18535/jmscr/v4i11.115
Background: Cutaneous metastasis is one of the rare occurrence in clinical practice. Cases with skin metastases are diagnosed to have stage IV disease and curative treatment is not intended in most of the cases. Due to the ease of accessibility for clinical and pathological examination its diagnosis and treatment plays great value. Cases: Here we report nine cases with pathological diagnosis of skin metastases from different primaries from January 2015 to March 2016. Conclusion: Development of multiple skin metastases indicates poor survival and co-existence of extra-cutaneous metastases makes survival even worse. Thorough metastatic workup and evaluation is necessary. Treatment is mostly palliative. Key Words: Skin Nodules, Skin Metastases.
1. Asuquo, M.E., Umoh, M.S. and Bassey, E.E. (2010) Cutaneous Metastatic Carcinoma: Diagnostic and Therapeutic Values. Advances in Skin & Wound Care, 23, 77-80. http://dx.doi.org/-10.1097/01.ASW.0000363504.92360.5f 2. Helm, T.N., Lee, T.C., Elston, D.M., Heymann, W.R., Schwartz, R.A. and Wells, M.J. (2014) Dermatologic Manifestation of Metastatic Carcinomas. http://emedicine.-medscape.com/article/1101058-overwiew 3. Asuquo, M.E., Umana, A.N., Nwagbara, V.I.C., Nnoli, M. and Ugbem, T. (2016) Cutaneous Metastatic Disease: Case Series in a Tropical Setting. Case Reports in Clinical Medicine, 5, 25-31. http://dx.doi.org/10.4236/crcm.2016.51005 4. Schoenlaub P, Sarraux A, Grosshans E, Heide E, Cribier B: Survival after cutaneous metastasis: a study of 200 cases (in French). Ann DermatolVenereol2001, 128:1310–1315 5. Lookingbill DP, Spangler N, Helm KF: Cutaneous metastases in patients with metastatic carcinoma: a retrospective study of 4020 patients. J Am AcadDermatol 1993, 29:228–236. 6. Nesseris, I., Tsamakis, C., Gregoriou, S., Ditos, I., Christofidou, E. and Rogopoulos, D. (2013) Cutaneous Metastasis of Colon Adenocarcinoma: Case Report and Review of the Literature. Anais Brasileiros de Dermatologia, 88, 556- 558. 7. Pereina, W.A., Humaine, C.R., Silia, C.S. and Fermandos, L.H. (2011) Sister Mary Joseph’s Nodule a Sign of Internal Malignancy. Anais Brasileiros de Dermatologia, 86, 118-120 8. Kilickap, S., Aksoy, S., Dincer, M., Saglam, E.A. and Yalcin, S. (2006) Cutaneous Metastasis of Signet Cell Carcinoma of the Rectum without Accompanying Visceral Involvement. Southern Medical Journal, 99, 1137-1139. 9. Bansal R ,Naik R., A study of 70 cases of cutaneous metastases from internal carcinoma, J Indian Med Assoc. 1998 Jan;96(1):102. 10. Schwartz RA, Cutaneous metastatic disease, J Am AcadDermatol. 1995 Aug;33(2 Pt 1):16182; quiz 1836. 11. Hu SC, Chen GS, Lu YW, Wu CS, Lan CC. J EurAcadDermatolVenereol. 2008 Jun;22(6):735-40. doi: 10.1111/j.1468-3083.2008.02590.x. Epub 2008 Feb 26. 12. Kauffman CL, Sina B. Metastatic inflammatory carcinoma of the rectum: tumor spread by three routes. Am J Dermatopathol 1997; 19: 528-532.
Abstract