Cloacogenic carcinoma is a rare tumor originating from epithelium of the anal transition zone of embryonic residuals. It accounts for only 2%–3% of all neoplasm arising in the anorectal canal and has clinical and morphological characteristics that distinguish them from the ordinary varieties of adenocarcinoma and squamous cell carcinoma of the anorectum. We report here a case of a middle aged male who presented to us with history of altered bowel habits, pain during defecation, passage of fresh blood in stools and pruritus in anal region and on examination there was an ulcerative growth in the anal canal. The diagnosis of basaloid variety of cloacogenic carcinoma was made upon biopsy and histopathological examination. Patient was put on chemoradiation and responded well with complete disappearance of growth macroscopically and clinically but was then lost in follow-up.Owing to the paucity of published literature on this rare malignant tumor this case is being reported here.

Key Words: Cloacogenic carcinoma, basaloid, anal canal, chemoradiation, complete resolution.

1.      Olofinlade O, Adeonigbagbe O, Gualtieri N, Gingold B, Berlin I, Sayeed R, et al. Anal carcinoma: a 15-year retrospective analysis. Scandinavian journal of gastroenterology. 2000;35(11):1194-9.

2.      Serota AI, Weil M, Williams RA, Wollman JS, Wilson SE. Anal cloacogenic carcinoma: Classification and clinical behavior. Archives of Surgery. 1981;116(4):456-9.

3.      Gillespie JJ, MacKay B. Histogenesis of cloacogenic carcinoma. Fine structure of anal transitional epithelium and cloacogenic carcinoma. Human pathology. 1978;9(5):579-87.

4.      Akbulut S. What is the clinicopathological characteristic of cloacogenic carcinoma outside the anorectal zone? Hepato-gastroenterology. 2011;58(105):52-5.

5.      Naito Y, Hotta T, Yamamoto H, Iwamoto K, Murakami S, Tomimatu J, et al. A case of cloacogenic carcinoma originated from anal gland, presented as a rectal submucosal mass. Nippon Shokakibyo Gakkai Zasshi. 1988;85(2):281-6.

6.      Levy R, Czernobilsky B, Geiger B. Cytokeratin polypeptide expression in a cloacogenic carcinoma and in the normal anal canal epithelium.

7.      Shia J. An update on tumors of the anal canal. Archives of pathology & laboratory medicine. 2010;134(11):1601-11.

8.      Han S, Ji S, Guo S, Li W. Cloacogenic carcinoma of anal canal: two case reports and review of Chinese literature. Chin -Ger J ClinOncol. 2010;9(5):302-4.

9.      Dujovny N, Quiros RM, Saclarides TJ. Anorectal anatomy and embryology. Surgical oncology clinics of North America. 2004;13(2):277-93.

10.  Nigro ND. An evaluation of combined therapy for squamous cell cancer of the anal canal. Dis Colon Rectum. 1984;27(12):763-6.

11.  Indinnimeo M, Cicchini C, Stazi A, Limiti MR, Ghini C. An unusual location of cloacogenic carcinoma. International surgery. 1998;83(4):343-6.

12.  Fayaz S, Vasishta S, Motawy M. Case report of long term survivor of metastatic cloacogenic carcinoma of the anal canal with chemotherapy. The Gulf journal of oncology. 2007(2):65-8.

13.  Bertani E, Chiappa A, Mazzarol G, Contino G, Lazzari R, Zampino MG, et al. Aggressive Treatment Approach for Cloacogenic Carcinoma of the Anorectum: Report from a Single Cancer Center. Digestive surgery. 2010;27(4):297-301.

14.  Shindo K, Bacon H. Transitional-cell cloacogenic carcinoma of the perianal region, anal canal, and rectum. Dis Colon Rectum. 1971;14(3):222-5.

15.  Peppe H, Bianchi C, Bianchi O, Stringa S. [Cutaneous metastasis of a cloacogenic tumor]. Medicinacutaneaibero-latino-americana. 1987;15(4):293-7.

16.  Salmon RJ, Zafrani B, Labib A, Asselain B, Girodet J. Prognosis of cloacogenic and squamous cancers of the anal canal. Dis Colon Rectum. 1986;29(5):336-40.