Novel Thiazoles Derivatives Containing Methoxy-Napthyl Moiety as Potent Anti-Bacterial and Anti-Tubercular Agents and Its Characterization

Title: Novel Thiazoles Derivatives Containing Methoxy-Napthyl Moiety as Potent Anti-Bacterial and Anti-Tubercular Agents and Its Characterization

Authors: V. J .Chandraprabha, D. Jagadeesh Prasad, Kumar.C, Prashantha Nayak

DOI: https://dx.doi.org/10.18535/jmscr/v4i11.42

Abstract

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Abstract

Thiazoles and their derivatives have attracted continuing interest in both pharmaceutical and agrochemical industries and shows significant importance for the discovery of potent bioactive agents due to their various biological activities.

The present study reports the synthesis of novel 2-{2-[(6-methoxynaphthalen-2-yl) methylidene] hydrazinyl}-4-(aryl)-1, 3-thiazole (5a-5j) which was synthesized by acid hydrolysis of 6-methoxynaphthalene-2-carbaldehyde (1) and hydrazinecarbothioamide (2) which was refluxed for around 10 hours using alcohol as solvent, to yield (2E)-2-[(6-methoxynaphthalen-2-yl) methylidene] hydrazinecarbothioamide (Thiosemicarbozone) (3). The compound (3) was then condensed with different substituted phenacyl bromide (4) at 90^oC for 8-9 hours .The structures of newly synthesized compounds were characterized by IR,¹H-NMR,¹³C -NMR and mass spectroscopic studies, few of the synthesized compounds showed moderate anti-TB activities and compounds (5d) showed moderate activity against M.tuberculosis (H37 RV Strain).Among the compounds screened for antibacterial activity (5c), (5e), (5g) and (5h) showed excellent antibacterial activity.

Keywords: 1, 3- thiazoles, Anti-bacterial and Anti-tubercular activity studies.

References

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