Abstract
This report explores the transformative impact of pharmacogenomics on the field of anesthesia, focusing on tailoring anesthesia to individual patients. Pharmacogenomics investigates genetic variations influencing responses to anesthetic agents, offering insights into drug metabolism, receptor sensitivity, and overall pharmacokinetics. The integration of genetic data into anesthesia practice enables personalized medicine by optimizing drug selection and dosages based on an individual's genetic profile. Key considerations include the influence of genetic polymorphisms in drug metabolism enzymes, such as cytochrome P450, and the role of genetic variations in drug receptor genes. The report addresses challenges and ethical considerations associated with implementing pharmacogenomics in routine anesthesia practice. Adopting the potential of pharmacogenomics in molding the future of anesthesia care sustains promise for enhancing patient safety and results in the perioperative context.
Keywords: Pharmacogenomics, Individual patients, Anesthetic agents, Drug.
References
- Saba, R., Kaye, A. D., & Urman, R. D. (2017). Pharmacogenomics in anesthesia. Anesthesiology Clinics, 35(2), 285-294.
- Bach-Rojecky, L., Čutura, T., Lozić, M., Kliškinjić, I. H., Matišić, V., & Primorac, D. (2021). Personalized Anesthetic Pharmacology. Personalized Medicine in Anesthesia, Pain and Perioperative Medicine, 65-92.
- Zarei, S., Costas, Y., Orozco, G., Zaydlin, M., Mirtar, A., Abouali, M., ... & Mirzakhani, H. (2020). A web-based pharmacogenomics search tool for precision medicine in perioperative care. Journal of Personalized Medicine, 10(3), 65.
- Mohammadi-Yeganeh, S., Bilanicz, S., & Dabbagh, A. (2021). The Role of OMICS (Genomics, Epigenetics, Transcriptomics, Proteomics and Metabolomics) in Personalized Anesthesia and Perioperative Medicine. Personalized Medicine in Anesthesia, Pain and Perioperative Medicine, 9-63.
- Mohammadi-Yeganeh, S., Bilanicz, S., & Dabbagh, A. (2021). The Role of OMICS (Genomics, Epigenetics, Transcriptomics, Proteomics and Metabolomics) in Personalized Anesthesia and Perioperative Medicine. Personalized Medicine in Anesthesia, Pain and Perioperative Medicine, 9-63.
- Mahmoodpoor, A. (2021). Personalized Anesthesia for Lungs and Respiratory Tract. Personalized Medicine in Anesthesia, Pain and Perioperative Medicine, 117-132.
- Daley, M. D., & Greenberg, J. S. (2020). Demystifying pharmacogenomic implications for the anesthesia provider(Doctoral dissertation, Rutgers University-School of Nursing-RBHS).
- Samardzic, J., Svob Strac, D., & van den Anker, J. N. (2017). The benefit and future of pharmacogenetics. Total Intravenous Anesthesia and Target Controlled Infusions: A Comprehensive Global Anthology, 697-711.
- Dorgalaleh, A., Bahraini, M., & Ahmadi, S. E. (2021). Personalized anesthesia in hematology. Personalized medicine in anesthesia, pain and perioperative medicine, 231-274.
- Riddle, J. D. (2015). Clinical Utility of Pharmacogenomic Testing to Support Prescriptive Decision Making Among Anesthesia Providers: A Mixed-Method Study. Medical University of South Carolina.
Corresponding Author
Abdullatif Eid Alghamdi
Specialist in Anesthesia Technology
DOI: https://dx.doi.org/10.18535/jmscr/v11i12.10
