Abstract
A child aged 5 years female, complained of lower back pain for 5 months during defecation. Per-rectal examination revealed a swelling in retrorectal presacral region. She was operated. A tumour, measuring 8×5×5 cm was excised. Histopathological examination of the tumour revealed presence of large number of ganglion cells and schwann cells in loose myxomatous fibrillary stroma. Tumour tissue revealed positivity for S100, desmin and neuron-specific enolase (NSE). In addition, mild positive reaction (1+) was obtained with anti-Sox-10 antibody. Negative reaction was obtained with anti-Ki 67 and anti-chromogranin antibodies. Tumour was finally diagnosed as ganglioneuroma.
Keywords: Benign Ganglion cells, Schwann cells, S100 positivity.
References
- Lack EA, Farber JL, Rubin E. Ganglioneuroma 3rd ed. The endocrine system, chapter 21. In ‘Pathology’, Rubin E, Farber JL (editors) Lipincott-Raven, volume II,1999,1199-1200.
- Bapir R, Hawrami TA, Aghaways I, Ali RM, Hiwa DS, Husseim DM, et al. A huge retroperitoneal ganglioneuroma in a middle-aged patient: Report of diagnostically challenging case with review of the literature. Oncology letters 2022; 24(6) https// doi org10.3892 ol.2022.13569.
- Lack EE, Gruhn JG. Adrenal gland, chapter 63, In ‘Anderson's Pathology’, 10th ed, Mosby, New York, Damjanov I, Linder J (editors) Þ 2035.
- Goldblum JR, Folpe AL, Weiss SW. Benign tumors of peripheral nerves Chapter 67. In Enzinger and weiss's soft tissue tumors, 6th ed. Elsevier Saunders, Philadelphia 2014,791-2.
- Bove KE, McAdanus AJ. Composite ganglioneuroblastoma: and assessment of the significance of histological maturation in neuroblastoma diagnosed beyond infancy. Arch Pathol Lab Med 1981.105; 325.
- Shawa H, Elsayes KM, Javadi S, Morani A, Williams MP, Lee JE. Adrenal ganglioneuroma: features of 27 cases at a referral cancer centre. 2013;80:342-7.
- Weedon D, Strutton G. Neural and neuroendocrine tumors, chapter 37, In Skin Pathology, Churchil Livingstone, Edinburgh 1995, Þ805.
- Radice F, Gianotti. Cutaneous ganglion cell tumour of the skin. Case report and review of literature. Amer J Dermatopathol 1993;15:488-91.
- Miettinen M, Weiss SW. Soft tissue tumors, chapter 72,1996, p2508-2509. In ‘Anderson's Pathology’, vol 2, Damjanav ID, Linder J(ed.) Mosby, St Louis (publishers).
- Saadat S, Friz C, Tran D, Parry N, Yuhan BT, Bolduon AB et al. A systemic review of cervical ganglioneuroma. Amer Acad Otolaryngology- Head and neck surgery 2022, 6 (2) 1-6.
- Li Fei, Feng H, Liao J, Bao Y, Xu S, Qin G. Parapharyngeal space ganglioneuroma: clinical experience and review of the literature. Ear, nose, throat J 2022; 1-7.
- Goldman R, Winterling A, winterling C. Maturation of tumors of the sympathetic nervous system. Cancer 1965;18:1510-1516.
- Aguirre P, Scully RE. Testosterone-secreting adrenal ganglioneuroma containing Leydig cells. Am J Surg Pathol 1983;7:699.
- Hayes FA, Green AA, Rao BN, Clinical manifestations of ganglioneuroma. Cancer 1989; 63:1211-14.
- Rubin E, Farber JL. Neoplasia. In ‘Pathology’ 3rd Chapter 5,1999, Þ 162. Lippincott-Raven, Philadelphia (publishers).
- Mounasamy V, Thacker MM, Humble S, Azouz ME, Pitcher JD, Scully SP. Ganglioneuromas of the sacrum- a report of two cases with radiologic-pathologic . Skeletal Radiol. 2006; 35: 117-21.
- Cerullo G, Marrelli D, Rampone B, Miracoo C, Caruso S, Marianna DM. Presacral ganglioneuroma: A case report and review of literature 2007, 13 (14): 2129-31.
- Leeson MC, Hite M. Ganglioneuroma of the sacrum. Clin Orthop Rel Res 1989;102:105.
- Stout AP, Ganglioneuroma of the sympathetic nervous system. Surg Gynecol Obstet 1947: 84: 101-10.
- Bernardi BD, Gambini C, Haup R, Granata C, Rijjo A, Conte M. Retrospective study of childhood ganglioneuroma. J Clin Oncol 2008;26: 1710-16.
Corresponding Author
Dr. Ashok Kumar Kapoor
RML Mehrotra Pathology Pvt. Ltd, Nirala Nagar, Lucknow, Uttar Pradesh, India
DOI: https://dx.doi.org/10.18535/jmscr/v11i2.18
