Abstract
A condition of purine metabolism, gout is characterised by sporadic bouts of acute inflammation, pain, swelling and redness of joint. It is usually preceded by hyperuricemia related to increased uric acid synthesis or reduced excretion which leads to monosodium urate deposits in soft tissues and synovial joints, known as tophi.
Keywords: Hyperuricemia; tophi; gout.
References
- Harrold LR, Etzel CJ, Gibofsky A, et al. Sex differences in gout characteristics: Tailoring care for women and men. BMC Musculoskelet Disord. 2017. 14; 18: 108. doi: 10.1186/s12891- 017-1465-9.
- Wortmann RL, Kelley WN. Gout and hyperuricemia. Harris ED, Budd RC, Genovese MC, Firestein GS, Sargent JS, Sledge CB, editors., eds. Kelley's textbook of rheumatology, 7th edn Philadelphia, Pennsylvania, USA: Elsevier Saunders; 2005: 1402-29.
- Schlee S, Bollheimer LC, Bertsch T, Sieber CC, Härle P. Crystal arthritides - gout and calcium pyrophosphate arthritis: Part 2: Clinical features, diagnosis and differential diagnostics. Z GerontolGeriatr. 2017; doi: 10.1007/s00391-017-1198-2.
- Iacobellis G. A rare and asymptomatic case of mitral valve tophus associated with severe gouty tophaceous arthritis. J Endocrinol Invest. 2004, 27 (4):965-966.
- EvangelosFalidas, Efstathios Rallis, Vasiliki-KalliopiBournia, Stavros Mathioulakis, EmmanouilPavlakis and ConstantinosVillias. Multi articular chronic tophaceous gout with severe and multiple ulcerations: a case report. Journal of Medical Case Reports. 2011, 5:397.
- Campion EW, Glynn RJ, DeLabry LO: Asymptomatic hyperuricemia. Risks and consequences in the Normative Aging Study. Am J Med. 1987, 82: 421-10.1016/0002-9343(87)90441-4.
- Urano W, Yamanaka H, Tsutani H, Nakajima H, Matsuda Y, Taniguchi A, Hara M, Kamatani N: The inflammatory process in the mechanism of decreased serum uric acid concentrations during acute gouty arthritis. J Rheumatol. 2002, 29 (9): 1950-3.
- Hollingworth P, Scott JT, Burry HC: Nonarticular gout: hyperuricemia and tophus formation without gouty arthritis. Arthritis Rheum. 1983, 26: 98-101. 10.1002/art.1780260117.
- Sutaria S, Katbamna R, Underwood M: Effectiveness of interventions for the treatment of acute and prevention of recurrent gout – a systematic review. Rheumatology (Oxford). 2006, 45: 1422-10.1093/rheumatology/kel071.
- Janssens HJ, Janssen M, Lisdonk van de EH, van Riel PL, van Weel C: Use of oral prednisolone or naproxen for the treatment of gout arthritis: a double-blind, randomised equivalence trial. Lancet. 371 (9627): 1854-60. 10.1016/S0140-6736(08)60799-0. 2008 May 31.
Corresponding Author
Dr Garima
Junior resident, Department of Ophthalmology, RPGMC, Tanda, Kangra, H.P. India