Abstract
Aim: To assess the maternal, perinatal, and Neonatal effects of COVID-19 infection in Pregnant women.
Methods: A prospective study was performed at Sudha Hospital and Research Institute for 12 months from February 2021 to February 2022.This study was carried out on 78 pregnant women with COVID-19 infection admitted with or without symptoms. Their treatment and outcome of pregnancy were studied.
Results: Majority of patients 71.1% presented with symptoms like fever, cough, sore throat and myalgia. There was no significant increase in the incidence of oligohydramnios, preterm labour and Meconium aspiration. Newborn intensive care is significantly needed for babies born during an infective period around 18.4%
Conclusion: In the current scenario, pregnant women are more vulnerable to COVID-19 infection. The course, effect and outcome of infection remain still an unsolved problem. Further many studies are necessary to conclude about the after-effects of COVID infection in pregnant women.
Keywords: COVID-19, maternal, neonate, oligohydramnios, high-risk pregnancies.
References
- World Health Organization. WHO Director-General's opening remarks at the media briefing on COVID-19 – 11 March 2020.https://www.who.int/dg/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-COVID-19—11-march-2020.
- Li MY, Li L, Zhang Y, Wang XS. Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues. Infect Dis Poverty 9: 45, 2020.
- Soy M, Keser G, Atagündüz P, Tabak F, Atagündüz I, Kayhan S. Cytokine storm in COVID-19: pathogenesis and overview of anti-inflammatory agents used in treatment. ClinRheumatol 39: 2085–2094, 2020.
- Dashraath, P., Wong, J.L.J., Lim, M.X.K., et al. (2020) Coronavirus Disease 2019 (COVID-19) Pandemic and Pregnancy. American Journal of Obstetrics & Gynecology, 222, 521-531.
- Grein J, Ohmagari N, Shin D, Compassionate Use of Remdesivir for Patients with Severe COVID-19. N Engl J Med. 2020 Jun 11;382(24):2327-2336.
- MagalaSsekandi A, Sserwanja Q, Olal E, Kawuki J, Bashir Adam M. Corticosteroids Use in Pregnant Women with COVID-19: Recommendations from Available Evidence. J Multidiscip Healthc. 2021;14:659-663.
- Coronavirus (COVID‐19) Infection in Pregnancy – Version 10.1 [19 June 2020] London, UK: RCOG; 2020
- Chen YH, Keller J, Wang IT, Lin CC, Lin HC. Pneumonia and pregnancy outcomes: a nationwide population-based study. Am J Obstet Gynecol. 2012;207(4):288.e1-288.e2887. doi:10.1016/j.ajog.2012.08.023
- Ryan, Gillian A et al. “Clinical update on COVID-19 in pregnancy: A review article.” The journal of obstetrics and gynaecology research vol. 46,8 (2020): 1235-1245. doi:10.1111/jog.14321
- Gao, Yi-Jie et al. “Clinical features and outcomes of pregnant women with COVID-19: a systematic review and meta-analysis.” BMC infectious diseases vol. 20,1 564. 3 Aug. 2020, doi:10.1186/s12879-020-05274-2
- Burwick RM, Yawetz S, Stephenson KE, Collier AY, Sen P, Blackburn BG, Kojic EM, Hirshberg A, Suarez JF, Sobieszczyk ME, Marks KM, Mazur S, Big C, Manuel O, Morlin G, Rose SJ, Naqvi M, Goldfarb IT, DeZure A, Telep L, Tan SK, Zhao Y, Hahambis T, Hindman J, Chokkalingam AP, Carter C, Das M, Osinusi AO, Brainard DM, Varughese TA, Kovalenko O, Sims MD, Desai S, Swamy G, Sheffield JS, Zash R, Short WR. Compassionate Use of Remdesivir in Pregnant Women With Severe Coronavirus Disease 2019. Clin Infect Dis. 2021 Dec 6;73(11):e3996-e4004.
- Aliji, Nurije, and FilonidAliu. "Oligohydramnion in COVID19." European Journal of Obstetrics and Gynecology and Reproductive Biology 249 (2020): 102.
- Di Renzo GC, Giardina I. Coronavirus disease 2019 in pregnancy: consider thromboembolic disorders and thromboprophylaxis. Am J Obstet Gynecol. 2020;223(1):135. doi:10.1016/j.ajog.2020.04.017
- Villar J, Ariff S, Gunier RB, et al. Maternal and Neonatal Morbidity and Mortality Among Pregnant Women With and Without COVID-19 Infection: The INTERCOVID Multinational Cohort Study. JAMA Pediatr. 2021;175(8):817–826. doi:10.1001/jamapediatrics.2021.1050
Corresponding Author
Dr Pradeepa Sudhakar, DGO., DNB (OG)
Senior Consultant, IVF and ART Specialist, Department of Reproductive Medicine, Sudha Hospital, Erode, Tamil Nadu, India
DOI: https://dx.doi.org/10.18535/jmscr/v11i1.13
