Abstract
Adenocarcinoma of the lung is the most common primary lung carcinoma seen globally. It falls under the group of non-small cell lung cancer (NSCLC) and has a strong established association with tobacco smoking. Due to the presence of numerous carcinogens present in tobacco smoke, primary or secondary exposure increases risk proportional to the amount of exposure. Other risk factors include family history of lung cancer or occupational exposure to agents like silica , asbestos, radon, heavy metals and diesel fumes, however the incidence with these agents are less prevalent when compared to tobacco exposure. As the name indicates, adenocarcinoma of the lung originates from the mucosal glands and represents approximately 35 to 40% of all lung cancers. The peculiarity of adenocarcinoma of the lung is that, it is the most common subtype to be diagnosed in people who have never smoked. Lung adenocarcinoma usually occurs in the lung periphery and may be found in scars or areas of chronic inflammation. Lung Adenocarcinoma in young is generally rare and mean age for lung malignancy is 65 years or older.
Keywords: Adenocarcinoma, Lung , Crazy Paving Pattern, Lepidic Growth.
References
- Bennett DE, Sasser WF, Ferguson T: Adenocarcinoma of the lung in men. A clinicopathologic study of 100 cases. Cancer1969; 23:431-439.
- Vincent TN, Satterfield JV, Ackerman LV: Carcinoma of the lung in women. Cancer1965; 18:559-570.
- McElvaney G, Miller RR, Muller NL, Nelems B, Evans KG, Ostrow DN: Multicentricity of adenocarcinoma of the lung. Chest1989; 95:151-154.
- Dessy E, Pietra GG: Pseudomesotheliomatous carcinoma of the lung. An immunohistochemical and ultrastructural study of three cases. Cancer 1991; 68:1747-1753.
- Harwood TR, Gracey DR, Yokoo H: Pseudomesotheliomatous carcinoma of the lung. A variant of peripheral lung cancer. Am J Clin Pathol1976; 65:159-167.
- Moran CA: Pulmonary adenocarcinoma: the expanding spectrum of histologic variants. Arch Pathol Lab Med 2006; 130:958-962.
- Kodama T, Shimosato Y, Koide T, Watanabe S, Yoneyama T: Endobronchial polypoid adenocarcinoma of the lung. Histological and ultrastructural studies of five cases. Am J Surg Pathol1984; 8:845-854.
- Kerr KM: Pulmonary adenocarcinomas: classification and reporting. Histopathology 2009; 54:12-27.
- Linnoila RI: Pathology of non-small cell lung cancer. New diagnostic approaches. Hematol Oncol Clin North Am1990; 4:1027-1051.
- Terasaki H, Niki T, Matsuno Y, Yamada T, Maeshima A, Asamura H, Hayabuchi N, Hirohashi S: Lung adenocarcinoma with mixed bronchioloalveolar and invasive components. Am J Surg Pathol2003; 27:937-951.
- Shikha S. Immunotherapy Resistance in Non-Small Cell Lung Cancer. Oncol Cancer Case Rep. 2021, 07(9), 001-001.
- Gui X, Ding J, Li Y, Yu M, Chen T, Huang M, et al. Lung carcinoma with diffuse cystic lesions misdiagnosed as pulmonary langerhans cell histocytosis: a case report. BMC Pulm Med. 2020; 20: 30.
- Rogers C, Kent-Bramer J, Devaraj A, Nicholson AG, Molyneaux PL, Wells AU, et al. Rapidly progressive cystic lung disease. Am J Respir Crit Care Med. 2018; 198: 264.
- Shannon VR, Nanda AS, Middleton LP, Faiz SA. Pulmonary mucinous cystadenocarcinoma presenting as extensive multifocal cystic lesions. Am J Respir Crit Care Med. 2017; 195: 1267–8.
- Zhang J, Zhao YL, Ye MX, Sun G, Wu H, Wu CG, et al. Rapidly progressive diffuse cystic lesions as a radiological hallmark of lung adenocarcinoma. J Thorac Oncol. 2012; 7: 457–8.
Corresponding Author
Dr Mahesh Gudelli
Consultant Interventional Pulmonologist, Yashoda Hospital, Secunderabad
DOI: https://dx.doi.org/10.18535/jmscr/v11i1.05
