Abstract

 Introduction

• End stage renal disease /Chronic Kidney Disease is a clinical syndrome caused by different underlying renal pathology.
• The cardio vascular disease is the leading cause of death in End stage renal disease/Chronic Kidney Disease (Chronic Kidney Disease stages 3-5). These patients develop clinically silent myocardial injury.
• Hence, a clinically silent Cardiac pathology underlies these cardiac troponin T elevations. This elevated cardiac troponin T is a specific marker of myocardial cell injury in patients of End stage renal disease/Chronic
• Kidney Disease because of high organ specificity of cardiac troponin T.
• The Increase in plasma concentration of the cardiac troponin T protein, clearly indicates myocardial cell injury.
• Cardiovascular complications like myocardial injury in End stage renal disease/Chronic Kidney Disease (Chronic Kidney Disease stages 3-5) occurs very early in the progression of Chronic Kidney Disease.
• Hence early detection of myocardial injury by measuring cardiac troponin T will help to detect and treat the cardiac complications in End stage renal disease/Chronic Kidney Disease (Chronic Kidney Disease stages 3-5).
• Cardiac Troponin T, a Tropomyosin-binding protein of the regulatory complex located on the contractile apparatus of cardiac myocytes.
• It is elevated in non ischemic type of chronic myocardial injury and can be used as a marker of cardiac myocytes injury.

Aims & Objectives

• To determine whether serum cardiac Troponin T is elevated in patients with End stage renal disease/Chronic Kidney Disease (Chronic Kidney Disease stages 3-5).
• Early detection of myocardial cell injury by estimating serum cardiac Troponin T levels in patients with End stage renal disease/Chronic Kidney Disease (Chronic Kidney Disease stages 3-5).