Abstract
Background: Lung fibrosis is being reported as one of the complications of COVID-19pulmonary pneumonia, and it is one of the long-term complications of Covid-19. Fibrosis is associated with non-reversible lung dysfunction with reduced lung functions. The aim of this study is to diagnose, early detection and predict the prognosis of such patients whom may develop such serious complication, thus early introduction of anti-fibrotic drugs to save them from lung damage.
Methods & Results: From April 2022 to May 2022, 100 patients in All India Institute of Medical Sciences, Patna, Bihar, who was confirmed COVID-19 by RT- PCR test, were evaluated by follow-up MDCT. A comparative study was done using follow-updata from the acquired CT images (different radiological signs and residual fibrotic changes).The cause for post-COVID-19 lung fibrosis is still unknown, however some predicting factors such as old age, cigarette smoking, high CT severity score, and long-term mechanical ventilation helps in predicting the prognosis of the patients.
Conclusions: MDCT provides helpful assessment in post-COVID-19 pulmonary fibrosis and other post-covid related complications. Sutiable aid like introduction of anti-fibrotic can be provided to the patients on time to avoid pulmonary complications.
Keywords: COVID-19, Lung fibrosis, RT-PCR, Severity score.
References
- Peter M, Athol U, Jenkins RG (2020) Pulmonary fibrosis and COVID-19: the potential rolefor antifibrotic therapy. Lancet 138:805–815
- George P, Patterson C, Ak R(2019) Lung transplantation for idiopathic pulmonary fibrosis. Lancet Respir Med 7(3):271–282.
- Carfì A,Bernabei R,Landi F (2020) For the Gemelli against COVID-19 post-acute care study group. Persistent symptoms in patients after acute COVID-19. J Am
- King CS, Nathan SD (2017) Idiopathic pulmonary fibrosis: effects and optimal management of comorbidities. Lancet Respir Med 5(1):72–84.
- Richeldi L, du Bois R, Raghu G et al (2014) Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis. N Engl J Med 370(22):2071–2082.
- Jr King, Bradford WZ, Castro-Bernardini S et al (2014) A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis. N Engl J MedAssoc324(6):603–605.
- Zarir F, Priyanka K, Awatansh K et al (2021) Fibrotic interstitial lung disease occurring as sequelae of COVID-19 pneumonia despite concomitant steroids. Lung India 38(1):1–105
- Carsana L, Sonzogni A, Nasr A et al (2020) Pulmonary post- mortem findings in a series of COVID-19 cases from northern Italy: A two-center descriptive study. Lancet Infect Dis 1473- 3099(20):30434–30435
- Wu C, Chen X, Yanping C et al (2020) Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan. China JAMA Intern Med 180(7):934– 943.
- Francone M, Iafrate F, Gorgio M et al (2020) Chest CT score in COVID-19 patients: correlation with disease severity and short- term prognosis. Eur Radiol 4:1–10
- Pan F, Ye T, Sun P, Gui S, Liang B, Li L, Zheng D, Wang J, Hesketh RL, Yang L, Zheng C (2020) Time course of lung changes at chest CT during recovery from coronavirus disease 2019 (COVID-19). Radiology 295(3):715–721.
- Tale S, Ghosh S, Meitei SP et al (2020) Post-COVID-19 pneumonia pulmonary fibrosis. Int J Med 113(11):837–838.
- Ademola S, Simon A, Oyeronke T et al (2020) Pulmonary fibrosis in COVID- 19 survivors: predictive factors and risk reduction strategies. Pulmon Med 5: 1–10
- George PM, Wells AU, Jenkin RG et al (2020) Pulmonary fibrosis and COVID- 19: the potential role for antifibrotic therapy. Lancet Respir Med 8(8):807– 815. https://doi.org/10.1016/S2213-2600(20)30225-3
- Wong K, Antonio GA, Hui DS et al (2002) Severe acute respiratory syndrome: thin-section computed tomography features, temporal changes, and clinicoradiologic correlation during the convalescent period. J Comput Assisted Tomogr 28(6):790–795
- Sansone A, Mollaioli D, Ciocca G, Limoncin E, Colonnello E, Vena W, Jannini EA (2021) Addressing male sexual and reproductive health in the wake of COVID-19 outbreak. J Endocrinol Invest. 44(2):223–231.
- Lee EY, Singh R (2017) Follow-up chest radiographic findings in patients with MERS-CoV after recovery. Indian J Radiol Imag 27(3):342–349
- Vardavas CI, Nikitara K (2020) COVID-19 and smoking: a systematic review of the evidence. Tob Induc Dis..2020; 18:20
- Zhou F, Yu T, Du R et al (2020) Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 395(10229):1054–1062.
Corresponding Author
Dr Shashank Saurav
Senior Resident, Department of Radiodiagnosis, All India Institute of Medical Sciences, Patna, Bihar, India
DOI: https://dx.doi.org/10.18535/jmscr/v10i7.02
