Abstract
Ovarian Yolk sac tumor is the second most common Malignant ovarian Germ Cell tumor (MOGT). It is seen in young women of reproductive age group, presenting commonly as abdominopelvic mass. Here we present a hiatopathologically diagnosed case of large ovarian Yolk sac tumor in a 21 years old women who presented with abdomino-pelvic pain and swelling, raised AFP levels. She was treated with conservative surgery and currently undergoing chemotherapy.
References
- Dallenbach P, Bonnefoi H, Pelte MF. Yolk sac tumours of the ovary: an update. Eur J SurgOncol. 2006;32:1063-1075.
- Smith H.O., Berwick M., Verschraegen C.F., Wiggins C., Lansing L., Muller C.Y., et al.: “Incidence and survival rates for female malignant germ cell tumors”. Gynecol., 2006, 107, 1075.
- P. Maniar, R. Vang. Germ cell tumors of the ovary. In: Blaustein's Pathology of the Female Genital Tract (7th Ed.). Kurman RJ, Ellenson LH, Ronnett BM (eds.). Springe International Publication. 1047-1067, 2019.
- Sreehari, A. et al. Ovarian Yolk Sac Tumor: A Case Report with Review of Literature. Journal of Medical Sciences2 (2016): 15-17.
- Kato N, Tamura G, Fukase M, Shibuya H, Motoyama T. Hypermethylation of the RUNX3 gene promoter in testicular yolk sac tumor of infants. Am J Pathol 2003 Aug;163(2):387-391.
- Siltanen S, Anttonen M, Heikkila P, Narita N, Laitinen M, Ritvos O, Wilson DB, Heikinheimo M. Transcription factor GATA-4 is expressed in pediatric yolk sac tumors. Am J Pathol 1999 Dec;155 (6): 1823-1829.
- Kawai M, Furuhashi Y, Kano T, Misawa T, Nakashima N, Hattori S, Okamoto Y, Kobayashi I, Ohta M, Arii Y, et al. Alpha-fetoprotein in malignant germ cell tumors of the ovary. GynecolOncol. 1990 Nov;39(2):160-6.
- Cicin I, Saip P, Guney N. Yolk sac tumours of the ovary: evaluation of clinicopathological features and prognostic factors. Eur J Obstet Gynecol Reprod Biol. 2009;146:210-4.
- Eslier, C. Blanc-Fournier, F. Joly, S. Martin-Françoise. Pure yolk sac tumor of ovary in an adult: a rare occurrence. European Journal of Gynaecological Oncology, 2020, 41(2): 289-292
Corresponding Author
Dr Sarita Asotra
Associate Professor, Department of Pathology, IGMC Shimla
DOI: https://dx.doi.org/10.18535/jmscr/v10i4.16
