Title: A Retrospective Observational Study of Patients with High-Risk Gestational Trophoblastic Neoplasm treated at Chittagong Medical College Hospital
Authors: Dr Jannatun Nisa, Prof. Dr MD. Mokhles Uddin, Dr Syeda Umma Tasmia, Dr Fahmida Alam, Dr Sajjad Mohammad Yusuff
DOI: https://dx.doi.org/10.18535/jmscr/v10i4.06
Abstract
Objective: Gestational trophoblastic tumors are a spectrum of interrelated conditions arising from an abnormal fertilization, most of them are highly sensitive to chemotherapy & curable in metastatic disease also. The aim of the study was to observe the outcome of high-risk Gestational trophoblastic neoplasia in Bangladeshi perspective.
Methods: This is a retrospective observational study of 31 women of high-risk gestational trophoblastic neoplasia conducted at Radiotherapy Department of Chittagong Medical College Hospital over a period of 4.5 years from January 2013 to June 2018. Only the patients with high-risk characteristics were included in this study. All patients were treated with EMA-CO chemotherapy regimen as first line chemotherapy. Second line chemotherapy with EP/EMA was given to patients having poorer response to primary chemotherapy or showing progression of disease.
Results: Of the 31 patients 3 were lost to follow up during treatment & 28 patients were evaluated. Among 28 patients 22 (79%) patients achieved complete remission with EMA-CO regimen & 6(21%) patients become refractory to EMA-CO & received subsequent chemotherapy with EP/ EMA, VIP regimen.5 more patients achieved complete remission with 2nd and 3rd line chemotherapy. Thus, overall complete response rate was 96.43% (27/28).
Conclusion: In the present study a complete remission of 96.43% patients achieved which is comparable with other relevant studies. So, the preferred primary chemotherapy regimen in high-risk GTN is EMA-CO.
Keywords: Gestational trophoblastic tumors, EMA-CO chemotherapy.
