Abstract
Background: Wounds and their management are fundamental in the practice of surgery. A chronic ulcer of the foot is a frequent condition and is a major health challenge and growing health problem all over the world.
Aims & Objectives: To compare the efficacy of Platelet rich plasma and Superoxidised solution in the management of chronic foot ulcers to observe: Wound disinfection, Rate of wound healing, Appearance of granulation tissue, Duration of hospital stay.
Materials: Randomized prospective comparative study of patients with chronic non healing foot ulcers admitted at our hospital from October 2018 to January 2020, patients were randomized into 2 groups- PRP and SOS with 25 patients in each group. Wound assessments done at regular intervals and various wound outcome variables compared. Statistical analysis of data done.
Results: In a study of 50 patients, most patients were in the age group of 51- 60years, 76% were diabetics and 78% were males. There was a rapid decrease in wound size in PRP group compared to SOS group at day 21, and earlier appearance of granulation and epithelialization in PRP group. The duration of hospital stay was almost equal in both groups.
Conclusion: This study shows more favorable results for PRP as compared to SOS in healing of chronic non healing foot ulcers which are highly statistically significant.
Keywords: Platelet Rich Plasma, Superoxidised Solution, Chronic non healing foot ulcers.
References
- Mekkes JR, Loots MAM, Van Der Wal AC, Bos JD. Causes, investigation and treatment of leg ulceration. Br J Dermatol. 2003, 148: 388-401.
- The Inquirer (1805). What are the comparative advantages of the different modes proposed for the treatment of ulcerated legs? Edinburgh Medical and Surgical Journal, I, 187-193. This is a very lucid account of opinion in 1805 on the treatment of leg ulcers.
- Kahle, H. J. Hermanns, and G. Gallenkemper, ―Evidence-based treatment of chronic leg ulcers, Deutsches Ärzteblatt International, vol. 108, no. 14, pp. 231– 237, 2011.
- B. van Gent, E. D. Wilschut, and C. Wittens, ―Management of venous ulcer disease, The British Medical Journal, vol. 341, no. 7782, pp. 1092–1096, 2010.
- Reiber GE, Boyko E, Smith DG: Lower extremity ulcers and amputations in individuals with diabetes. In Diabetes in America, 2nd ed. Harris MI, Cowie CC, Stern MP, Boyko EJ, Reiber GE, Bennett PH, Eds. Washington, DC, U.S. Govt. Printing Office, 1995, p. 409–427 (NIH publ. no. 95-1468)
- V. González-Consuegra and J. Verdú, ―Quality of life in people with venous leg ulcers: an integrative review, Journal of Advanced Nursing, vol. 67, no. 5, pp. 926–944, 2011.
- VanitaKapur& Anil Kumar Marwaha Evaluation of Effect and Comparison of Superoxidised Solution (Oxum) V/S Povidone Iodine (Betadine) Indian J Surg
(January–February 2011) 73(1):48–53
- Anand, Ashok. "Comparative Efficacy and Tolerability of Oxum against Povidone
Iodine Topical Application in the Post-caesarean Section Wound Management."
Indian Med Gazette (2007): 498-505.
- Chittoria RK, Yootla M, Sampatrao, LM, Raman Sv The Role of Super Oxidized
Solution in the Management of Diabetic Foot Ulcer: Our Experience. Department of Plastic Surgery, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India, Nepal MED Coll. J. 2007 Jun;9(2):125-8.
- Vickie R Driver, Jason Hanft, Carelyn P Fylling. A prospective, randomized, controlled trial of autologous platelet-rich plasma gel for the treatment of diabetic foot ulcers. Ostomy wound management 2006;52(6):68-87.
- Knighton D, Ciresi K, Fiegel VD, Schumerth S, Butler E, Cerra F. Stimulation of repair in chronic, nonhealing, cutaneous ulcers using platelet-derived wound healing formula. Surg Gynecol Obstet. 1990;170(1):56-60.
- Frykberg RG, Driver VR, Carman D, Lucero B, Borris-Hale C, Fylling CP, et al. Chronic wounds treated with a physiologically relevant concentration of platelet- rich plasma gel: a prospective case series. Ostomy/Wound Manage. 2010;56(6):36-44.
Corresponding Author
Dr Sharath. A
Post graduate, Dept of General Surgery, Kempegowda Institute of Medical Sciences, Bengaluru, Karnataka