Abstract
Schizophrenia is a serious mental disorder with a long and painful course. It contributes significantly to the worldwide burden of disease caused by mental health conditions. Relapses are common in schizophrenia, and each one worsens clinical symptoms, cognitive impairment, social and vocational performance, and overall quality of life. Cariprazine is a new antipsychotic that acts as a partial D2, D3 receptor agonist with a preference for the D3 receptor over the D2 receptor, whereas many existing antipsychotics favor the D2.The dopamine D3 receptor, in particular, has been proposed as a potential target for the treatment of unipolar depression. When flexibly dosed at 3–9 mg/day for up to 48 weeks, cariprazine was typically safe and well tolerated in patients with schizophrenia. Cariprazine binds with high potency to D3 dopamine, D2 dopamine, and 5HT2B serotonin receptors, but only moderately to 5HT1A and 5HT2A serotonin receptors, a profile that differs from brexpiprazole and aripiprazole.
Keywords: schizophrenia, Cariprazine, dopamine D3 receptor, mental health disorders.
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Corresponding Author
Rama Lakshmi Devadi
Registered Pharmacist, Bridgeport, Connecticut- 06614
DOI: https://dx.doi.org/10.18535/jmscr/v10i1.01
