Abstract
Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9) has a vital role in lipid metabolism and pathophysiology of atherosclerosis. It is also reported to be associated with diabetes mellitus.
Objective: To determine PCSK9 enzyme levels in patients having coronary artery disease (CAD) with diabetes mellitus and to correlate the enzyme levels with severity of CAD based on angiogram reports.
Material and Methods: The present study was undertaken as a hospital based cross sectional study among 40 patients of either sex in the age group of 30-65 years who were already diagnosed to have CAD with diabetes mellitus. The study was carried out during the period starting from May 2018 to November 2018. Difference in means between two independent groups having non parametric distribution was tested using Mann Whitney U test. A p value <0.05 was considered statistically significant.
Results: Mean PCSK9 levels were found to be considerably high in patients with triple vessel disease as compared to those patients with one or two vessel involvements. For a PCSK9 cut off value of 51.5 ng/dl, the sensitivity and specificity for triple vessel disease was calculated to be 88.24% (65.7% -96.7%) and 95.65% (79%-99.2%), respectively
Conclusion: PCSK9 levels correlated significantly with number of vessels involved in CAD, as evaluated by angiography, among patients with CAD and DM. A PCSK9 cut off level of 51.5 ng/dl had remarkable sensitivity and specificity for triple vessel disease.
Keywords: Diabetes Mellitus, Coronary Artery Disease, Proprotein convertase subtilisin/kexin type 9 (PCSK9), Triple vessel disease.
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Corresponding Author
Balaji Venkateshwaran.M
Postgraduate Department of Medicine
DOI: https://dx.doi.org/10.18535/jmscr/v9i11.39
