Abstract
Objective: To estimate serum testosterone level in male patients of diabetes type 2 having metabolic syndrome.
Background: Major public health issue faced by the world in present century is diabetic mellitus and the prevalence is also increasing explosively, low testosterone levels in men is one of the diabetic related complication.
Methods: This was a prospective population based study of sixty seven diabetic male patients aged 36 – 70 years (median 56.36= 10.26) reaching emergency and OPD having metabolic syndrome and were evaluated for serum testosterone levels.
Results: sixty Seven male patients with type 2 diabetes mellitus were enrolled during the study period. The mean age of study population was 56.36±10.26 years (range 36-70), while that of control group patients was found to be 39.80±7.92years. The total number of patients who had BMI of more than 25 kg/ m2, were 19 and all these have low levels of testosterone (<241 ng/dl) which is significant (p value <0.001) .Total number of patient having triglyceride level> 150 mg/dl were 17 and all these have low levels of testosterone which is significant (p value <0.001) The mean HbA1c in study group was 8.83±1.95 %, which was significantly higher as compared to control group with HbA1c 4.82±0.40.
Conclusions: The present study highlighted that significant difference in serum total testosterone level has been observed in patients of metabolic syndrome (X2 =55.7, P=0.0001).
References
- Akishita M, Hashimoto M, Ohike Y, et al. Low testosterone level as a predictor of cardiovascular events in Japanese men with coronary risk factors. 2010; 210:232–236.
- Alberti KG,Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, Fruchart JC, James WP, Loria CM, Smith SC Jr; International Diabetes Federation Task Force on Epidemiology and Prevention; Hational Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society ; International Association for the Study of Obesity : Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation. 2009 Oct 20;120 (16):1640-5.
- Araujo AB, Dixon JM, Suarez EA, et al. Clinical review: Endogenous testosterone and mortality in men: a systematic review and meta-analysis. J Clin Endocrinol Metab. 2011;96:3007–3019.
- Bhasin S, Cunningham GR, Hayes FJ, et al. Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2010;95:2536–2559.
- Cheung KK,Lau ES2, So WY2, Ma RC3, Ozaki R2, Kong AP3, Chow FC2, Chan JC3, LukAO : Low testosterone and clinical outcomes in Chinese men with type 2 diabetes mellitus - Hong Kong Diabetes Registry. Diabetes Res Clin Pract. 2017 Jan;123:97-105.
- Corona G, Mannucci E, Petrone L, et al. NCEP-ATPIII-defined metabolic syndrome, type 2 diabetes mellitus, and prevalence of hypogonadism in male patients with sexual dysfunction. J Sex Med. 2007;4:1038–1045.
- Corona G, Monami M, Rastrelli G, et al. Testosterone and metabolic syndrome: a meta-analysis study. J Sex Med. 2011;8:272–283.
- Corona G, Monami M, Rastrelli G, et al. Testosterone and metabolic syndrome: a meta-analysis study. J Sex Med. 2011;8:272–283.
- Dandona P, Dhindsa S. Update: Hypogonadotropichypogonadism in type 2 diabetes and obesity. J Clin Endocrinol Metab. 2011;96:2643–2651.
- Gail A. Laughlin,Vivian Goodell, and Elizabeth Barrett-Connor : Extremes of Endogenous Testosterone Are Associated with Increased Risk of Incident Coronary Events in Older Women. J Clin Endocrinol Metab. 2010 Feb; 95(2): 740–747.
- Jankowska EA,Biel B, Majda J, Szklarska A, Lopuszanska M, Medras M, Anker SD, Banasiak W, Poole-Wilson PA, Ponikowski P : Anabolic deficiency in men with chronic heart failure: prevalence and detrimental impact on survival. Circulation. 2006 Oct 24;114(17):1829-37.
- Kitty Kit Ting Cheung,Andrea On Yan Luk, Wing Yee So, Ronald Ching Wan Ma, Alice Pik Shan Kong, Francis Chun Chung Chow, and Juliana Chung NgorChan : Testosterone level in men with type 2 diabetes mellitus and related metabolic effects: A review of current evidence. J Diabetes Investig. 2015 Mar; 6(2): 112–123.
- Kupelian V, Hayes FJ, Link CL, et al. Inverse association of testosterone and the metabolic syndrome in men is consistent across race and ethnic groups. J Clin Endocrinol Metab. 2008;93:3403–3410.
- Laaksonen DE, Niskanen L, Punnonen K, et al. Testosterone and sex hormone-binding globulin predict the metabolic syndrome and diabetes in middle-aged men. Diabetes Care. 2004;27:1036–1041.
- Liao CH, Huang CY, Li HY, et al. Testosterone and sex hormone-binding globulin have significant association with metabolic syndrome in Taiwanese men. Aging Male. 2012;15:1–6.
- Ohlsson C, Barrett-Connor E, Bhasin S, et al. High serum testosterone is associated with reduced risk of cardiovascular events in elderly men the mros (osteoporotic fractures in men) study in sweden. J Am CollCardiol. 2011;58:1674–1681.
- Ozkan Gungor, *Fatih Kircelli,* Juan Jesus Carrero, Gulay Asci,* Huseyin Toz,* Erhan Tatar,* Ender Hur,* Mehmet Sukru Sever, TurgayArinsoy,‡‖ and Ercan Ok: Endogenous Testosterone and Mortality in Male Hemodialysis Patients: Is It the Result of Aging? Clin J Am SocNephrol. 2010 Nov; 5(11): 2018–2023.
- Salminen M, Vahlberg T, Raiha I, et al. Sex hormones and the risk of type 2 diabetes mellitus: A 9-year follow up among elderly men in Finland. Geriatr Gerontol Int.
- Shores MM,Matsumoto AM, Sloan KL, Kivlahan DR: Low serum testosterone and mortality in male veterans. Arch Intern Med. 2006 Aug 14-28;166(15):1660-5.
- Simon D, Preziosi P, Barrett-Connor E, et al. Interrelation between plasma testosterone and plasma insulin in healthy adult men: the Telecom Study. Diabetologia. 1992;35:173–177.
Corresponding Author
Dr Sushmita
Senior resident KPS Institute of General Medicine Kanpur
DOI: https://dx.doi.org/10.18535/jmscr/v9i8.23
