Abstract
Objective: To investigate the frequency of abnormal Neuroimaging and abnormal electroencephalogram findings in pediatric seizure disorder
Methods: A total of 153 patients (ages between 1 month to 12 years) were included from inpatient, outpatient and emergency wards and evaluated as per standardized protocol over a period of 6 months . Seizure pattern was observed and routine investigations sent. CT scan was done in 93.4 %, MRI was done in 91.5%, and EEG was done in 83.6 % patients. Patients were categorized into provoked and unprovoked seizure, later investigations results were analysed in both groups
Results: Amongst the studied population generalized tonic clonic seizure was the most commonly observed seizure. MRI was found to be abnormal in 62.8% patients. EEG showed significant abnormality in 51.5%. Abnormal CT scan only in 46.1%. EEG and MRI were both found abnormal in 40.6% patients. There was a statistical significance between EEG and MRI at 99 CI (p<0.0001).
Conclusion: MRI and EEG form an essential part of evaluation for pediatric seizure disorder and often provide a deeper insight into the underlying abnormality. MRI is more sensitive for yield of white matter abnormalities than CT scan.
References
- Sridharan R, Murthy BN. Prevalence and pattern of epilepsy in India. Epilepsia 1999;40 631- 636.
- Hirtz D, Ashwal S, Berg A, Bettis D, Camfield C, Camfield P, Crumrine P, Elterman R, Schneider S, Shinnar S.et al. Practice parameter: evaluating a first nonfebrile seizure in children: report of the quality standards subcommittee of the American Academy of Neurology, the Child Neurology Society, and the American Epilepsy Society. Neurology 2000; Sep 12; 55(5):616-23.
- S. dosecher A study done on Magnetic Resonance Imaging and Electroencephalographic Findings in a Cohort of Normal Children With Newly Diagnosed Seizures. J Child Neurol. 2006 Jun; 21(6): 491–495.
- Shinnar S, Kang H, Berg AT, Goldensohn ES, Hauser WA, Moshe SL. EEG abnormalities in children with a first unprovoked seizure. Epilepsia. 1994;35:471–6. [PubMed
- Andrew J. Kalnin, MD, Philip S. Fastenau, PhD, Joan K. Austin, DNS. MR Imaging Findings in Children with First Recognized Seizure. Pediatric Neurology, 01 Dec 2008, 39(6):404-41.
- Dura ́-Trave ́a, M. E. Yoldi-Petria, J. Esparza-Estau ́nb, F. Gallinas-Victorianoa, S. Aguilera- Albesaa and A. Sagastibelza-Zabaletaa Magnetic resonance imaging abnormalities in children with epilepsy European Journal of Neurology 2012, 19:
- D T. Hsieh, T Chang, T N. Tsuchida, L G. Vezina,Aanderver, J Siedel on New-onset afebrile seizures in infants, Role of neuroimaging. Neurology. 2010 Jan 12; 74(2): 150–156.
- Shinnar S, Kang H, Berg AT, Goldensohn ES, Hauser WA, Moshe SL. EEG abnormalities in children with a first unprovoked seizure. Epilepsia. 1994;35:471–6. [PubMed]
- Shinnar S, Berg AT, Moshe SL, et al. The risk of seizure recurrence after a first unprovoked afebrile seizure in childhood: an extended follow-up. Pediatrics. 1996;98:216–25. [PubMed]
- Berg AT, Shinnar S. The risk of seizure recurrence following a first unprovoked seizure: a quantitative review. Neurology. 1991;41:965–72. [PubMed]
Corresponding Author
Nita R. Sutay
M.D., Fellowship in Pediatric Neurology, Professor and Head of the Department of Pediatrics , Sir, J.J. Hospital, Government Grant Medical College, Mumbai