Abstract
Introduction: Insertion of an intravascular catheter is the most common invasive procedure in the neonatal ICU (NICU). Central Lines (CL)s including Umbilical Venous Catheter (UVC)s and Peripherally Inserted Central Catheter (PICC)s are often used in the care of neonates to provide arterial and venous access. However, the use of CLs is associated with several complications including infection(1),(2). For this reason, the decision to insert a CL should always be carefully considered for every patient individually, and the benefits must be weighed against the risks. The insertion and use of a CL expose the neonate to several potential risks and complications. The relative risk of sepsis is several times higher in a neonate with a CL(3). The present study is an attempt to obtain actual data on the incidence of complications associated with central line insertions in our Neonatal ICU.
Aim: Aim of the study is to provide data on the use of Umbilical Venous Catheters and Peripherally Inserted Central Catheters in newborn infants admitted to our neonatal ICU and to study complications and their rates of occurrences.
Methods: All neonates admitted to the Neonatal Intensive Care Unit (NICU) at the Kovai Medical Centre and Hospital (KMCH) in the period from April 2018 until March 2019, who needed at least one Central Line during their hospitalization, were included. The study design is a Prospective Observational Study. The data were entered into the SPSS spreadsheet and double-checked. The analysis was done in SPSS version 20.0 for windows.
Results: Of all the Indications for the lines, prolonged use/TPN constituted the most – 82 (50.9%) out of which umbilical lines constituted 32 (39%) and PICC lines constituted 50 (61%). Several sites have been used for inserting PICC lines. The most common site being the Right Great Saphenous Vein (GSV). 46 out of 56 PICC lines have been secured in Right GSV which constituted 82.1 % of all PICCs. The second commonest being Left GSV – 7 (12.5%). Out of all the complications that occurred, Umbilical lines were found to have 8 complications (7.62% of all Umbilical lines) whereas PICC lines had 9 complications (16 % of all PICC lines). There were 17 complications in total which accounted for 10.55%. PICC lines have been found to have a greater number of complications and are statistically significant when compared to UVCs. Three cases of thrombophlebitis have been reported in our study. It constituted to 5.3% of all the PICC lines. Of the 7 occlusions that were reported, as many as 6 (85.7% of all occlusions and 10.7% of all PICC lines) have been in PICC lines whereas Umbilical lines had only 1 occlusion. Of the 2 extravasations that were reported, one was in UVC and the other was in the PICC group.
Conclusion: Most common indication for a central line in a neonate was poor venous access and prolonged use of TPN. Malposition in PICC lines was associated with a greater number of complications. Hence great care must be taken in the following line placed in an inappropriate position. Ongoing efforts are required to assure that the catheter does not migrate. Central Venous Catheters must be removed as soon as their potential risks outweigh their benefits. Umbilical Venous Catheters are usually safe upto 10 – 14 days. PICCs are usually safe for up to 4 weeks following which it is prudent to secure a new line and remove the existing line. Manipulating or handling these Central Lines without following proper hand hygiene practices increases the risk of infections.
Keywords: Central Venous Catheters, PICC Lines, Malposition, Infections.
References
- Alshafei A, Tareen F, Maphango N, White D, O’Connor B, Sriparan T. Open tunneled central line insertion in children − external or internal jugular vein? J Pediatr Surg. 2018; 53:2318–2321
- Arul GS, Lewis N, Bromley P, Bennett J. Ultrasound-guided percutaneous insertion of Hickman lines in children. A prospective study of 500 consecutive procedures. J Pediatr Surg 2009; 44:1371–1376.
- Arul GS, Livingstone H, Bromley P, Bennett J. Ultrasound-guided percutaneous insertion of 2.7 Frtunneled Broviac lines in neonates and small infants. Pediatr SurgInt 2010; 26:815–818.
- Auyong DB, Hsiung RL. Ultrasound in central venous cannulation. Adv Anesth 2010; 28:59–79.
- Avanzini S, Guida E, Conte M, Faranda F, Buffa P, Granata C et al. Shifting from open surgical cut down to ultrasound-guided percutaneous central venous catheterization in children: learning curve and related complications. PediatrSurgInt 2010; 26:819–824. Back to cited text no. 17
- Bannon MP, Heller F, Rivera M. Anatomic considerations for central venous cannulation. Risk ManagHealthc Policy 2011; 4:27–39. Back to cited text no. 5
- Blum LV, Abdel-Rahman U, Klingebiel T, Fiegel H, Gfroerer S, Rolle U. Tunneled central venous catheters in children with malignant and chronic diseases: a comparison of open vs. percutaneous implantation. J PediatrSurg 2017; 30:30. Back to cited text no. 16
- Davis MH. Pediatric central venous catheter management: a review of current practice. JAVA 2013; 18:93–98. Back to cited text no. 3
- Fragen M, Gravvanis A, Dimitriou V, Papalois A, Kouraklis G, Karabinis A et al. Real-time ultrasound-guided subclavian vein cannulation versus the landmark method in critical care patients: a prospective randomized study. Crit Care Med 2011; 39:1607–1612. Back to cited text no. 11
- Fratino G, Molinari AC, Parodi S, Longo S, Saracco P, Castagnola E, Haupt R. Central venous catheter-related complications in children with oncological/hematological disease: an observational study of 418 devices. Ann Oncol 2005; 16:648–654. Back to cited text no. 12
- Hosseinpour M, Mashadi MR, Behdad S, Azarbad Z. Central venous catheterization in neonates: comparison of complications with percutaneous and open surgical methods. J Indian Assoc Pediatr Surg 2011; 16:99–101
- Karakitsos D, Nikolaos L, De Groot E, Patrianakos AP, Kouraklis G, Poularas J et al. Real-time ultrasound-guided catheterization of the internal jugular vein: a prospective comparison with the landmark technique in critical care patients. Crit Care 2006; 10:162–175. Back to cited text no. 14
- Lorenz JM, Funaki B, Van Ha T, Leef JA. Radiologic placement of implantable chest ports in pediatric patients. AJR 2001; 176:991–994. Back to cited text no. 24
- Loveday HP, Wilson J, Pratt RJ, Golsorkhi M, Tingle A, Bak et al. Epic3: national evidence-based guidelines for preventing healthcare-associated infections in NHS hospitals in England. J Hosp Infect 2014; 86:S1–S70.
- Maizel J, Bastide MA, Richecoeur J, Frenoy E, Lemaire C, Sauneuf B et al. Practice of ultrasound-guided central venous catheter technique by the French intensivists: a survey from the BoReal study group. Ann Intensive Care 2016; 6:76–78.
- Massicotte MP, Dix D, Monagle P, Adams M, Andrew M. Central venous catheter-related thrombosis in children: analysis of the Canadian registry of venous thromboembolism complications. J Pediatr 1998; 133:770–776.
- McMullan C, Propper G, Schuhmacher C, Sokoloff L, Harris D, Murphy P, Greene WH. A multidisciplinary approach to reduce central line-associated bloodstream infections. Jt Comm J Qual Patient Saf 2013; 39:61–69.
- Nixon SJ. Death after inserting the Hickman line was probably avoidable. BMJ 2002; 324:739.
- Prabhu V, Juneja D, Gopal PB, Sathyanarayanan M, Subhramanyam S, Gandhi S, Shivan and KN. Ultrasound-guided femoral dialysis access placement: a single-center randomized trial. Clin J Am Soc Nephrol 2010; 5:235–239.
- Sandoval D, Srceva MJ, Todorova ZN. Comparative analysis of ultrasound-guided central venous catheterization compared to blind catheterization. Pril (Makedon Akad Nauk Unmet Odd Med Nauki) 2017; 38:107–114. Back to cited text no. 8
- Taylor JE, McDonald SJ, Tan K. Prevention of central venous catheter-related infection in the neonatal unit: a literature review. J Matern Fetal Neonatal Med 2015; 28:1224–1230. Back to cited text no. 2
- Troiano's CA, Hartman GS, Glas KE, Skubas NJ, Eberhardt RT, Walker JD, Reeves ST. Guidelines for performing ultrasound-guided vascular cannulation: recommendations of the American Society of Echocardiography and the Society of Cardiovascular Anesthesiologists. JASE. 2011; 24:1291–1318.
- Verghese ST, McGill WA, Patel RI, Sell JE, Midgley FM, Ruttimann UE. Ultrasound-guided internal jugular venous cannulation in infants: a prospective comparison with the traditional palpation method. Anesthesiology 1999; 91:71–77. Back to cited text no. 25
- Vierboom R, Darani A, Langusch C, Soundappan SVS, Karpelowsky J. Tunnelled central venous access devices in small children: a comparison of open vs. ultrasound-guided percutaneous insertion in children weighing ten kilograms or less. Journal of Pediatric Surgery 2018; 53:1832–1838.
- Willetts IE, Ayodeji M, Ramsden WH, Squire R. Venous patency after open central-venous cannulation. Pediatr SurgInt 2000; 16:411–413.
Corresponding Author
Dr K Rajendran
Professor & Head, Department of Paediatrics & Neonatology, KMCH Institute of Health Sciences & Research, Coimbatore, Tamil Nadu India