Abstract
Aim: To study the efficacy of Nano crystalline silver in the management of diabetic foot ulcers
Methods: patients with diabetic foot ulcer were divided into two Groups using randomized number generator. Group 1 was test group for Nano silver gel dressing & group 2 was control group for conventional dressing. The effect of each dressing was compared for reduction in wound size, time to full granulation and number of hospital days.
Results: In our study there was no statistical significant different in the size of ulcer in the pre-treatment phase across case and control group. Final size of ulcer after the treatment was found to be statistically significant across case and control group (9.56±2.8 cm VS 13.24± 3.85), P value was <0.001. The mean granulation day in the test group was 17.22 ± 4.27 days, while among the control group 22.02 ±3.98 days, this difference in the mean was found to be significant (p<0.001). Difference in the duration of hospital stay across test and control group was 24.46 ± 4.89 days, 33.56 ± 4.59 days respectively. This difference was found to be significant (p<0.001). Thus in the test group mean size of ulcer after the dressing was smaller in test group than control group, mean granulation days and mean duration of stay was lesser in the test group.
Conclusion: In this study, there was significant reduction in wound size, the time for full healthy granulation appearance and the duration of hospital stay was better compared to the conventional dressing.
Keywords: Diabetic foot, Diabetic foot ulcer, nano silver gel.
References
- Winter GD. Formation of scab and rate of epithelialization of superficial wounds in the skin of the young domestic pig. Nature 1962;193:293-4.
- Cho CY, Lo JS. Excision and repair: Dressing the part. Dermatol Clin 1998; 16:25-47.
- Moon CH, Crabtree TG. New wound dressing techniques to accelerate healing. Curr Treat Options Infect Dis 2003;5: 251-60.
- Varghese MC, Balin AK, Carter DM, Caldwell D. Local environment of chronic wounds under synthetic dressings. Arch Dermatol 1986; 122: 52-7.
- Alvarez OM, Mertz PM, Eaglstein WH. The effect of occlusive dressings on collagen synthesis and reepithelialization in superficial wounds. J Surg Res 1983; 35:142-8.
- Rubio PA. Use of semiocclusive, transparent film dressings for surgical wound protection: An experience in 3637 cases. IntSurg1991;76:253-4.
- Lineaweaver W, Howard R, Soucy D, Mc Morris S, Freeman J, Crain C et al. Topical antimicrobial toxicity. Arch Surg 1985;120:267-70.
- White RJ, Cutting K, Kingsley A. Topical antimicrobials in the control of wound bioburden. Ostomy Wound Manage 2006;52:26-58.
- Tsang KK, Kwong EW, To TS, Chung JW, Wong TK. A pilot randomized, controlled study of nanocrystalline silver, manuka honey, and conventional dressing in healing diabetic foot ulcer. Evidence-Based Complementary and Alternative Medicine. 2017;2017
- Qari FA, Akbar D. Diabetic foot: presentation and treatment. Saudi medical journal. 2000;21(5):443-6.
- A. Fries, Y. Ayalew, J. G. Penn-Barwell, K. Porter, S. L. A. Jeffery, and M. J. Midwinter, “Prospective randomised controlled trial of nanocrystalline silver dressing versus plain gauze as the initial post-debridement management of military wounds on wound microbiology and healing,” Injury, vol. 45, no. 7, pp. 1111–1116, 2014..
- N. Miller, N. Newall, S. E. Kapp et al., “A randomized-controlled trial comparing cadexomer iodine and nanocrystalline silver on the healing of leg ulcers,” Wound Repair & Regeneration, vol. 18, no. 4, pp. 359–367, 2010.
Corresponding Author
Ajay.P (MS General Surgery)
Senior Resident, Mahatma Gandhi Medical College, Pondicherry
DOI: https://dx.doi.org/10.18535/jmscr/v9i2.23
