Abstract
Objective: The purpose of present study was to evaluate the RBS, ALP, and zinc in the individuals having T2DM and to compare the study parameters with healthy controls of Bundelkhand region. The other aim was to analyze the association between study parameters in healthy control subjects group and T2DM subjects group.
Results: We observed an insignificant in age in the present study when compared between the two groups. Whereas, comparison between two groups, of parameters such as the values of RBS, ALP, and serum zinc we observed a significant difference. In the patient group, positive correlation was observed between ALP versus zinc and a negative correlation was observed between age and RBS; RBS and serum zinc. In the control group, we found positive correlation between ALP and zinc.
Conclusion: In conclusion, we have demonstrated as zinc depletion aggravates insulin resistance and may result in increased loss through urine, it may be advisable to periodically monitor zinc concentrations in T2DM subjects.
Keywords: Type 2 Diabetes mellitus, Alkaline phosphatase, Hyperglycemia, Zinc.
References
- Selvakumar G, Shathirapathiy G, Jainraj R, Paul PY. Immediate effect of bitter gourd, ash gourd, knol-khol juices on blood sugar levels of patients with Type 2 diabetes mellitus: A pilot study. Journal of traditional and complementary medicine. 2017 Oct 1;7(4):526-31.
- Giacco F, Brownlee M (2010) Oxidative stress and diabetic complications. Circulation research 107(9), 1058-1070.
- Kontush A, Chapman MJ. Why is HDL functionally deficient in type 2 diabetes?. Current diabetes reports. 2008 Feb 1;8(1):51-9.
- Rains, J. L., & Jain, S. K. (2011). Oxidative stress, insulin signaling, and diabetes. Free Radical Biology and Medicine, 50(5), 567-575
- Anderson, R. A., Cheng, N., Bryden, N. A., Polansky, M. M., Cheng, N., Chi, J., & Feng, J. (1997). Elevated intakes of supplemental chromium improve glucose and insulin variables in individuals with type 2 diabetes. Diabetes, 46(11), 1786-1791.
- Kinlaw WB, Levine AS, Morley JE, Silvis SE, McClain CJ. Abnormal zinc metabolism in type II diabetes mellitus. The American journal of medicine. 1983 Aug 1;75(2):273-7.
- Peschke E, Stumpf I, Bazwinsky I, Litvak L, Dralle H, Mühlbauer E. Melatonin and type 2 diabetes–a possible link?. Journal of pineal research. 2007 May;42(4):350-8.
- Lowell BB, Shulman GI. Mitochondrial dysfunction and type 2 diabetes. Science. 2005 Jan 21;307(5708):384-7.
- Nsonwu AC, Usoro CA, Etukudo MH, Usoro IN. Serum and urine levels of chromium and magnesium in type 2 diabetics in Calabar, Nigeria. Malaysian Journal of Nutrition. 2005;11(2):133-42.
- Chen SC, Tsai SP, Jhao JY, Jiang WK, Tsao CK, Chang LY. Liver fat, hepatic enzymes, alkaline phosphatase and the risk of incident type 2 diabetes: a prospective study of 132,377 adults. Scientific reports. 2017 Jul 5;7(1):1-9.
- De A, Puttannavar R, Rahman F, Adak A, Sahoo R, Prakash BR. Estimation of salivary and serum alkaline phosphatase level as a diagnostic marker in type-2 diabetes mellitus with periodontal health and disease: a clinico-biochemical study. Journal of Oral and Maxillofacial Pathology: JOMFP. 2018 Sep;22(3):445.
- Olmos JM, Perez-Castrillon JL, Garcia MT, Garrido JC, Amado JA, Gonzalez-Macias J. Bone densitometry and biochemical bone remodeling markers in type 1 diabetes mellitus. Bone and Mineral. 1994 Jan 1;26(1):1-8.
- Lumachi F, Camozzi V, Tombolan V, Luisetto G. Bone mineral density, osteocalcin, and bone‐specific alkaline phosphatase in patients with insulin‐dependent diabetes mellitus. Annals of the New York Academy of Sciences. 2009 Sep 1;1173:E64-7.
- Dzúrik R, Stefíková K, Spustová V, Fetkovská N. The role of magnesium deficiency in insulin resistance: an in vitro study. Journal of hypertension. 1991 Jan 1;9:S314.
- Eshak ES, Iso H, Maruyama K, Muraki I, Tamakoshi A. Associations between dietary intakes of iron, copper and zinc with risk of type 2 diabetes mellitus: A large population-based prospective cohort study. Clinical nutrition. 2018 Apr 1;37(2):667-74.
- da Silva Bandeira V, Pires LV, Hashimoto LL, de Alencar LL, Almondes KG, Lottenberg SA, Cozzolino SM. Association of reduced zinc status with poor glycemic control in individuals with type 2 diabetes mellitus. Journal of Trace Elements in Medicine and Biology. 2017 Dec 1;44:132-6.
- Samadi A, Isikhan SY, Tinkov AA, Lay I, Doşa MD, Skalny AV, Skalnaya MG, Chirumbolo S, Bjørklund G. Zinc, copper, and oxysterol levels in patients with type 1 and type 2 diabetes mellitus. Clinical Nutrition. 2020 Jun 1;39(6):1849-56.
- Asbaghi O, Sadeghian M, Fouladvand F, Panahande B, Nasiri M, Khodadost M, Shokri A, Pirouzi A, Sadeghi O. Effects of zinc supplementation on lipid profile in patients with type 2 diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials. Nutrition, Metabolism and Cardiovascular Diseases. 2020 Mar 28.
- Skalnaya MG, Skalny AV, Tinkov AA. Serum copper, zinc, and iron levels, and markers of carbohydrate metabolism in postmenopausal women with prediabetes and type 2 diabetes mellitus. Journal of Trace Elements in Medicine and Biology. 2017 Sep 1;43:46-51.
- Salmerón J, Ascherio A, Rimm EB, Colditz GA, Spiegelman D, Jenkins DJ, Stampfer MJ, Wing AL, Willett WC. Dietary fiber, glycemic load, and risk of NIDDM in men. Diabetes care. 1997 Apr 1;20(4):545-50.
- Meyer KA, Kushi LH, Jacobs Jr DR, Slavin J, Sellers TA, Folsom AR. Carbohydrates, dietary fiber, and incident type 2 diabetes in older women. The American journal of clinical nutrition. 2000 Apr 1;71(4):921-30.
- Elsheikh M, Elhefnawy KA, Emad G, Ismail M, Borai M. Zinc alpha 2 glycoprotein as an early biomarker of diabetic nephropathy in patients with type 2 diabetes mellitus. Brazilian Journal of Nephrology. 2019 Dec;41(4):509-17.
- Norouzi S, Adulcikas J, Sohal SS, Myers S. Zinc transporters and insulin resistance: therapeutic implications for type 2 diabetes and metabolic disease. Journal of Biomedical Science. 2017 Dec 1;24(1):87.
- Ruz M, Carrasco F, Rojas P, Basfi-Fer K, Hernández MC, Pérez A. Nutritional effects of zinc on metabolic syndrome and type 2 diabetes: mechanisms and main findings in human studies. Biological Trace Element Research. 2019 Mar 15;188(1):177-88.
- Keane WF, Brenner BM, De Zeeuw D, Grunfeld JP, McGill J, Mitch WE, Ribeiro AB, Shahinfar S, Simpson RL, Snapinn SM, Toto R. The risk of developing end-stage renal disease in patients with type 2 diabetes and nephropathy: the RENAAL study. Kidney international. 2003 Apr 1;63(4):1499-507
- Agrawal P, Arora S, Singh B, Manamalli A, Dolia PB. Association of macrovascular complications of type 2 diabetes mellitus with serum magnesium levels. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2011 Jan 1;5(1):41-4.
- Koenig W, Khuseyinova N, Baumert J, Meisinger C, Löwel H. Serum concentrations of adiponectin and risk of type 2 diabetes mellitus and coronary heart disease in apparently healthy middle-aged men: results from the 18-year follow-up of a large cohort from southern Germany. Journal of the American College of Cardiology. 2006 Oct 3;48(7):1369-77.
- Walter RM, Uriu-Hare JY, Olin KL, Oster MH, Anawalt BD, Critchfield JW, Keen CL. Copper, zinc, manganese, and magnesium status and complications of diabetes mellitus. Diabetes care. 1991 Nov 1;14(11):1050-6.
- Turner RC, Cull CA, Frighi V, Holman RR, UK Prospective Diabetes Study (UKPDS) Group. Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). Jama. 1999 Jun 2;281(21):2005-12.
- Navarro JF, Mora C, Macıéa M, Garcıéa J. Inflammatory parameters are independently associated with urinary albumin in type 2 diabetes mellitus. American Journal of Kidney Diseases. 2003 Jul 1;42(1):53-61.
- Viktorínová A, Tošerová E, Križko M, Ďuračková Z. Altered metabolism of copper, zinc, and magnesium is associated with increased levels of glycated hemoglobin in patients with diabetes mellitus. Metabolism. 2009 Oct 1;58(10): 1477-82.
Corresponding Author
Dr Prabhakar Singh Bais
Asst Prof. & Head, Department of Biochemistry -MLB Medical College & Hospital- JHANSI-284128