Abstract
Background and Objectives: Dyslipidemia is a major risk factor for cardiovascular disease. It includes high levels of triglyceride (TG), total cholesterol (T-cholestrol), low density lipoprotein cholesterol (LDL-c) and low level of high density lipoprotein cholesterol (HDL-c). Therefore it is important to know the lipid levels of community for early intervention and prevention of cardiovascular disease. The present study investigated the lipid levels of urban population of Shimla
Methods: A descriptive cross sectional study was conducted in a health centre at Shimla. 132 samples were tested in the individuals above 18 years of age. Blood samples following overnight fast was collected for determination of serum TG, T-cholestrol, LDL-c and HDL-c. According to the criteria of the National Cholestrol Education Program- Adult treatment Panel III (NCEP-ATP III), Dyslipidemia was classified into (a) Hyperlipidemia-TC >200mg/dl, TG>150mg/dl, (b)Hypercholestrolemia TC>200mg/dl (c) Hypertriglyceridemia TG>150mg/dl, (d) Atherogenic dyslipidemia TG>150 , LDLC>165
Results: A total number of 132 adult individuals were enrolled of which 80 (61%) and 52 (39%) were male and female respectively. Study found 32 hyperlipidemia, 30% atherogenic dyslipidemia,8% hypercholesterolemia and 30% hypertriglyceridemia. 35.60% had low HDL. 7.58% had high LDL. BMI was higher among females as compared to males.(p=<0.01)
Conclusion: Prevalence of atherogenic dyslipidemia and hyperlipidemia are common and female dyslipidemic patients are susceptible to develop higher BMI. Which calls for urgent lifestyle intervention strategies to prevent and manage this.
Keywords: Dyslipidemia, Hypercholestrolemia, hypertriglyceridemia.
References
- Rukhsana Rabeya,Mohammad Hayatun Nabi, Ariful Bari Chowdhary. Epidemiology of Dyslipidemia among Adult Population of Bangladesh. Rom. J. Diabetes, Nutr, Metab Dis.26(2)99-106. 2019.
- World Health Organization. The atlas of heart disease and stroke/Judith Mackay and George Mensah; with Shanthi Mendis and KURT Greenland. Geneva: World Health Organization 2004. http;//www.who.int/iris/handle/10665/43007(accessed on 12th October 2018).
- Natarajan P, Ray KK, Cannon CP. High density lipoprotein and coronary heart disease. J AM Coll Cardiol 55(13):1283-1299,2010.
- Smith S, Lall AM. A study on lipid profile levels of diabetics and non diabetics among Naini region of Allahabad, India. Turkish J Biochem 33(4):138-141.2008.
- Amarenco P, Labreuche J, Toubol PJ. High density lipoprotein-cholestrol and risk of stroke and carotid atherosclerosis. A systematic review. Atherosclerosis 196(2) 489-496,2008.
- Fruchart JC, Sacks F, Hermans MP, Assmann G, Brown WV, Ceska R et al. The Residual Risk Reduction Initiative: a call to action to reduce residual vascular risk in patients with dyslipidemia. Am J Cardiol 102(IOS)1K-34K.2008.
- Bhalodkar NC, Blum S, Rana T, Bhalodkar A, Kiitchappa R, Kim KS, et al. Comparison of levels of large and small high density lipoprotein cholesterol in Asian Indian men compared with Caucasian men in the Framingham offspring study. Am J Cardiol 94:1561-1563, 2004.
- Neaton JD, Wentworth D. Serum cholesterol, blood pressure, cigarette smoking, and death from coronary heart disease. Overall findings and differences by age for 316,099 white men. Multiple risk factor intervention trial research group. Arch Intern Med 152 (I):56-64, 1992.
- Yusuf S, Reddy S, ounpuu S, Anand S. Global burden of disease, part 1: general considerations, the epidemiologic transition, risk factors and impact of urbanization. Circulation 104(22):2746-2753,2001.
- Farzadfar F, Finucane MM, Danaei G. Global Burden of Metabolic Risk Factors for Chronic Diseases Collaborating Group (Cholestrol) National, regional and global trends in serum total cholesterol since 1980: systemic analysis of health examination surveys and epidemiological studies with 321 country –years and 3.0 million participants. Lancet 377(9765):578-586, 2011.
- Labreuche J, Touboul PJ, Amarenco P. Plasma triglyceride levels and risk of stroke and carotid atherosclerosis: A systemic review of the epidemiological studies. Atherosclerosis 203(2): 331-345,2009.
- Karthikeyan G, Teo KK, Islam S, McQueen MJ, Pais P, Wang X et al. Lipid profile, plasma apolipoproteins, and risk of a first myocardial infarction among Asians: An analysis from the INTERHEART study.J Am Coll Cardiol53(3):244-253.2009.
- Bakesiima R, Byakika-Kibwika P, Tumwine JK et al. Dyslipidemias in women using hormonal contraceptives: a cross sectional study in Mulago Hospital Family Planning Clinic , Kampala, Uganda. BMJ Open 8 (10):eo22338,2018.
- World Health Organization. Global status report on non communicable diseases 2010, Geneva. Accessed at: https://www.who.int/nmh/publications/ncd₋report-full-en.pdf
- Heng DM. Lee J. Chew SK. Tan BY. Hughes K. Chia KS. Incidence of Isschemic Heart Disease and Stroke in Chinese, Malays, and Indians in Singapore: Singapore Cardiovascular Cohort Study. Ann Accad Med Singapore29(2): 231-236,2000.
- Reddy KS. Cardiovascular disease in non Western countries. N Engl J Med 350(24):2438-2440.2004
- Li Qi, Xianbin D, Wenge T, Qin Li, Deqiang, M.Yulin W. Prevalence and Risk Factors Associated with Dyslipidemia in Chongqing. China. Int. J.Environ. Res. Public Health 12(10): 13455-13465,2015.
- Bener A, Mohammad AG, Ismail AN, Zirie M, Abdullatef WK, AI-Hamaq AQ. Gender and age- related differences in patients with the metabolic syndrome in a highly endogenous population. Bosn J Basic Med Sci 10(3):210-217,2010.
- Li Y,ZhaoL, Yu D, Ding G. The prevalence and risk factors of dyslipidemia in different diabetic progression stages among middle aged and elderly populations in China. PLoS One 13(10):e0205709, 2011.
- Cai L, Zhang L, Liu A, Li S, Wang P, Prevalence, awareness, treatment, and control of dyslipidemia among adults in Beijing, China. J Atheroscler Thromb19(2):159-168,2011.
- Wang S, Xn L, Jonas JB, You QS, Wang YX, Yang H. Prevalence and associated factors of dyslipidemia in the adult Chinese population. PLoS One 6(3),2011.
- Sharma U, Kishore J. Garg A, Anand T, Chakraborty M, Lali P, Dyslipidemia and associated risk factors in a resettlement colony of Delhi. J Clin Lipidol 7(6):653-660, 2013.
- Gupta R, Ravinder S. Rao, Misra A, Samin K. Sharma. Recent trends in epidemiology of dyslipidemias in India. Indian Heart Journal 69(3):382-392,2017.
- Bayram F, Kocer D, Gundogan K, Kaya A, Demir O, Coskun R et al. Prevalence of dyslipidemia and associated risk factors in Turkish adults. J Clin Lipidol 8(2):206-216,2014.
- O’Brien T. Nguyen TT, Zimmerman BR, Hyperlipidemia and diabetes mellitus. Mayo Clin Proc 73(10):969-976,1998.
- Misra A and Shrivastava U. Obesity and Dyslipidemia in South Asians. Nutrients 5(7):2708-2733, 2013.
- Gebel Erika. A matter of the sexes:the differences between men and women with diabetes. Diabetes Forecast 64(10):46-49, 2011.
- Hillier TA, Pedula KL. Characteristics of an Adult Population with Newly Diagnosed Type 2 Diabetes. The relation of obesity and age of onset. Diabetes care 24(9): 1522-1527, 2001.
Corresponding Author
Dr Meenu Aggarwal
Resident Medical Officer Indian Institute of Advanced Study Shimla