Abstract
Background: As the initial step in pathogenesis of Acute coronary syndrome is plaque erosion, rupture and thrombus formation. Mean platelet volume (MPV) correlates with platelet function and activation. Mean platelet volume can be used as a diagnostic parameter in patients with Acute Coronary syndrome. The primary objective of this study is to find out the association between mean platelet volume and Acute Coronary syndrome.
Methods: Our study included 50 cases with acute coronary syndrome and 50 controls who were selected based on inclusion and exclusion criteria. Mean platelet volume estimated by auto-analyser is compared between ST-elevation Myocardial infarction, Non- ST-elevation Myocardial infarction and control group.
Results: The mean value of mean platelet volume among those with diagnosis STEMI, NSTEMI and CONTROL was 11.09 ± 1.046 fl, 10.5 ± 0.54fl, and 7.84 ± 0.375 fl respectively. The mean was found to be statistically significant for each diagnosis.
Conclusion: Our study concluded that mean platelet volume is higher in patients with STEMI than NSTEMI but in control group mean platelet volume found to be normal .Hence mean platelet volume can be used as a diagnostic marker in Acute coronary syndrome.
Keywords: Acute coronary syndrome, STEMI, NSTEMI, Mean platelet volume.
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Corresponding Author
Dr Ramakrishna Rao
Professor, Department of General Medicine, Rajah Muthiah Medical College and Hospital, Chidambaram, India, 608002
DOI: https://dx.doi.org/10.18535/jmscr/v8i11.63
