Abstract
Objective: To determine the Bacteriological Profile and Sensitivity Pattern in Neonatal Sepsis in the Nursery of a Tertiary Care Centre in Bareilly.
Method: A prospective observational study was conducted in the Department of Pediatrics, Rohilkhand Medical College and Hospital, Bareilly, over a period of one year (November2018– October 2019) on 140 patients, after getting clearance from the ethical Committee. All babies were admitted in NICU with risk factors or clinical features of neonatal sepsis or those evaluated for sepsis during their admission period, were included in the study, after taking written consent from their parents. A detailed history and thorough examination were done of all babies enrolled and their sepsis screen was sent.
Results: The sepsis screen analysis of all the enrolled patients showed that, out of all sepsis positive cases, 30% cases had a gram-positive infection while 70% cases had a gram-negative infection. 40% cases of all Gram-positive sepsis patients had Staphylococcus aureus infection, while 42% cases of Gram-negative sepsis patients had Klebsiella pneumoniae infection.
It was observed that >50% Gram positive organisms were sensitive to Meropenem, Piperacillin + Tazobactam, Amikacin and Vancomycin. While >50% Gram negative organisms were sensitive to Meropenem and Piperacillin + Tazobactam.
Conclusion: Thus, it can be concluded from the data that an empirical antibiotic therapy of Piperacillin + Tazobactam and Amikacin would be most efficacious in our set up as first line antibiotics rather than the combination of Cefotaxime and Amikacin which were being used up till now.
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Corresponding Author
Niraj Kumar
Junior Resident, Department of Pediatrics, Rohilkhand Medical College and Hospital, Bareilly, Utter Pradesh
DOI: https://dx.doi.org/10.18535/jmscr/v8i11.55
