Abstract
Background: The lifetime risk of heart failure is 20 - 45% corresponding to age and race. Many studies in the past have debated whether uric acid as undependable risk factor in heart failure and its influence on left ventricular ejection fraction.
Objective: The aim of our study is to correlate the serum uric acid level and andit’s influence on left ventricular ejection fraction in patients with established heart failure.
Methods: We conducted a prospective study that included 150 patients with established heart failure admitted in Rajah Muthiah Medical college and hospital based on selection criteria during the study period from October 2018 to October 2020.The study included patients with heart failure due to chronic arterial hypertension and coronary artery disease and it excludes patients with heart failure due to congenital heart disease, valvulopathies, severe anaemia, and patients with Gout, malignancy, and autoimmune diseases.
Results: There was a statistically significant(p=0.001) correlation between serum uric acid level and Left Ventricular Ejection fraction but there is no significant correlation between uric acid and other risk factors such as Diabetes, systemic hypertension and smoking.
Conclusion: High levels of serum uric acid are significantly correlated with the low levels of ejection fraction and this study also indicate that uric acid is an important prognostic factor in heart failure.
Keywords: Uric Acid, Left Ventricular Ejection fraction, Heart failure.
References
- McMurray, J.J.V., Cherubini, A., Ble, A., Bos, A.J.G., Maggio, M., Dixit, V.D., et al. (2014) Uric Acid and Inflammatory Markers. European Heart Journal, 27, 1174-1181. https://doi.org/10.1093/eurheartj/ehi879.
- Anker, S.D., Granner, D.K., Mayes, P.A. and Rodwell, V.W. (2012) Harper’s Illu- strated Biochemistry. Molecular Physiology.
- Adamopoulos, S., Anker, S.D., Auricchio, A., Böhm, M., Dickstein, K., et al. (2012) ESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Fail- ure. European Heart Journal, 33, 1787-1847.
- Ogino K, Kato M, Furuse Y, et al. UA-lowering treatment with benzbromarone in patients with HF a double-blind placebo- controlled crossover preliminary study. Circulation: HF. 2010;3:73–81.
- Leyva, F., Anker, S.D., Godsland, I.F., Teixeira, M., Hellewell, P.G., Kox, W.J., et al. (1998) Uric acid in Chronic Heart Failure: A Marker of Chronic Inflammation. Eu- ropean Heart Journal, 19, 1814-1822. https://doi.org/10.1053/euhj.1998.1188.
- Harzand, A., Palacio, A., Verma, S., Jones, J., Hare, J., et al. (2016) Uric Acid as a Predictor of All-Cause Mortality in Heart Failure: A Meta-Analysis. Congestive Heart Failure, 17, 25-30. https://doi.org/10.1111/j.1751-7133.2011.00200.x.
- Deveci, T., Takeishi, Y., Arimoto, T., Okuyama, H., Nozaki, N., Hirono, O., et al. (2013) Hyperuricemia Associated with High Cardiac Event Rates in the Elderly with Chronic Heart Failure. Journal of Cardiology, 47, 219-228.
- Filippatos GS, Ahmed MI, Gladden JD, Aban IB, Love TE, Sanders PW, et al. Hyperuricemia, chronic kidney disease, and outcomes in heart failure: potential mechanistic insights from epidemiological data. Eur Hear J. 2011;32(6):712–20.
- Deveci, O.S., Kabakci, G., Okutucu, S., Tulumen, E., et al. (2010). The Association between Serum Uric Acid Level and Coronary Artery Disease. ClinPract, 64, 900–907.
Corresponding Author
Dr Senthilvelan M
Professor & Head of the Department, Department of General Medicine, Rajah Muthiah Medical College and Hospital, Chidambaram, India, 608002
DOI: https://dx.doi.org/10.18535/jmscr/v8i11.52
