Title: Correlation between interleukin- 6 and Creatine kinase - MB in acute coronary syndrome – A hospital based descriptive study
Authors: Dr S.Ranjith Pratap, Dr M.Senthilvelan M.D., Dr K.Baburaj M.D.
DOI: https://dx.doi.org/10.18535/jmscr/v8i11.42
Abstract
Background: Biomarkers are used in the diagnosis, risk stratification, therapeutic decision making and assessment of clinical outcomes of a patient with ACS. Interleukin -6 (IL-6) is a glycoprotein of about 26kDa molecular weight. It is responsible for various activities ranging from proinflammatory activities.
Objectives: 1. To find out the mean IL-6 levels and mean CK-MB levels among the patients with myocardial infarction. 2. To find out the difference in mean IL-6 and Mean CK-MB levels between those suffering from STEMI, NSTEMI and Unstable angina. 3. To correlate IL 6 levels with CK -MB levels among patients with myocardial infarction.
Methodology: The present study was a hospital based descriptive study carried out in the department of medicine, Rajah Muthiah Medical College and Hospital, Annamalai University between September 2018 to October 2020 among the patients admitted with chest pain and ECG changes. All the data collected will be entered into Microsoft excel 2019 and master chart was created. The excel sheet was then imported into SPSS (statistical package for social sciences) version 23 for further analysis
Results: The mean value of Creatine kinase MB among the study participants was found to be 66.78 ± 35.698mg/l. The mean value of Creatine kinase -MB among those with diagnosis STEMI, NSTEMI and unstable angina was found to be statistically significant for each diagnosis. The mean value of IL-6 among the study participants was found to be 56.67 ± 22.761pg/ml. The mean value of IL-6 among those with diagnosis STEMI, NSTEMI and unstable angina was found to be statistically significant for each diagnosis. Both CK MB and IL-6 were strongly positively correlated with R value of 0.8 and P value of < 0.05.
Keywords: Acute coronary syndrome, Cardiac markers, Interleukin – 6, Creatine kinase -MB, STEMI, NSTEMI, Unstable angina.
