Abstract
Matrix metallo proteinases are a group of calcium, zinc dependent host derived enzymes which are trapped within the mineralized dentin matrix during tooth development. These enzymes are thought to induce the degradation of bonding interphase in the composite restorations. A recent review suggested that various exogenous MMP inhibitors, can inhibit dentin MMPs, preserve the dentin hybrid layer, and stabilize the adhesive interface and increase bonding strength. However the synthetic inhibitors have the disadvantage of high cytotoxicity, mismatched mechanical properties, or unsatisfied long-term stability. Proanthocyanidins (PAs), as natural cross-linking agents, overcome some of these drawbacks and have been successfully used in the pretreatment of biological tissues to improve their mechanical properties. Recent studies have shown them to have the capability to control the MMPs activity. The objective of this study was to evaluate the effect of pretreatment with pomegranate peel extract on the shear bond strength of a two-step etch and rinse system. Study was carried out in two main groups of teeth samples (control and PPE treated). Half of of the samples in the both groups were subjected aging process. The shear bond strength was tested for all the samples. Results were compared with Immediate and aged samples. Even though mean shear bond strength was slightly higher for PPE treated 2ndgroups, it showed that there was no statistically significant difference in bond strength for four groups
Keywords: Matrix metalloproteinase, Proanthocyanidin, Hybrid layer, Dentin biomodification.
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Corresponding Author
Dr Sajana.E.M
Postgraduate Student, Department of Conservative Dentistry and Endodontics, Sri Sankara Dental College, Varkala
DOI: https://dx.doi.org/10.18535/jmscr/v8i11.22
