Abstract
Introduction
Coronavirus disease (COVID-19) a disease caused by the novel virus (SARS-CoV-2) has become a global pandemic threat. Starting from Wuhan, China in December 2019,it has now spread across the world affecting 32.7 millian people & 9,92,000 deceased till September . SARS-CoV-2 is primarily transmitted between people through respiratory droplets. It can bind to the angiotensin-converting enzyme 2 (ACE2) receptor in the lungs. After which most people (80%) are asymptomatic or develop mild symptoms, such as coughing or fever.1 However, the disease can lead to more severe problems such as moderate to severe respiratory disease and some of them develop systemic complications like acute kidney injury, hepatitis, myocarditis, and disseminated coagulopathy.2,3 As the experience with the disease is increasing, neurological manifestations are being reported increasingly.4,5 We hereby describe three patients affected with COVID 19 who developed neurological manifestation in the form of neuropathy .
References
- Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, Liu L, Shan H, Lei CL, Hui DS, Du B. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020;382(18):1708–20
- Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395 (10223): 497–506.
- Bhatraju PK, Ghassemieh BJ, Nichols M, Kim R, Jerome KR, Nalla AK, Greninger AL, Pipavath S, Wurfel MM, Evans L, Kritek PA. Covid-19 in critically ill patients in the Seattle region—case series. N Engl J Med. 2020;382(21):2012–22
- Nath A. Neurologic complications of coronavirus infections. Neurology. 2020;94(19):809–10
- Mao L, Jin H, Wang M, Hu Y, Chen S, He Q, Chang J, Hong C, Zhou Y, Wang D, Miao X. Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA Neurol. 2020;77(6):683–90
- Imran Ahmad, Farooq Azam Rathore. Neurological manifestations and complications of COVID-19: A literature review, Journal of Clinical Neuroscience, 2020; 77: 8-12
- Helms, S. Kremer, H. Merdji, R. Clere-Jehl, M. Schenck, C. Kummerlen, etal.Neurologic Features in Severe SARS-CoV-2 Infection. N Engl J Med (2020), 10.1056/NEJMc2008597
- Mark A Ellul, Laura Benjamin, Bhateshwar Singh, Suzannah Lant, et al. Neurological associations of COVID-19. The Lancet Neurology. 2020;19(9): 767-783
- Abdelnour L, Eltahir Abdalla M, Babiker S. COVID 19 infection presenting as motor peripheral neuropathy. J Formos Med Assoc 2020; 119: 1119–20.
- Alberti P, Beretta S, Piatti M, et al. Guillain-Barré syndrome related to COVID-19 infection. Neurol – Neuroimmunol Neuroinflammation 2020; 7: e741.
Corresponding Author
Dr Sanjay Mundhe
Associate Professor, Dept of Medicine, BJGMC Pune
DOI: https://dx.doi.org/10.18535/jmscr/v8i10.37
