Abstract
In the last ten years, immune control point inhibitors (ICPI 'S) have been one of the most significant breakthroughs in cancer therapy. Different studies have reported desired clinical activity and durable response amongst advanced non-small cell lung cancer(NSCLC) patients in programmed cell death protein 1 ( Pd-1) and programmed death ligand 1 (PD-L1). Such findings have led to changes in the current advanced NSCLC therapy methods, and a new standard first-line treatment option has been introduced for patients with PD-L1 positives. In October 2016, the United States Food and Drug Administration (US FDA ) approved Pembrolizumab, a highly selective, humanised antipD-1 monoclonal antibody. Platinum-based chemotherapy is the first line treatment for advanced non-small cell lung cancer (NSCLC). Pembrolizumab replaced cytotoxic chemotherapy as the first line of treatment of choice in all patients with a tumour ratio score of 50% or higher for programmed death ligand 1 (PD-L1). Pembrolizumab was significantly higher in chemotherapy than chemotherapy with desirable responses and progressions free survival.
Keywords: Pembrolizumab, NSCLC, PD-L1, ICPI, Keytruda, Tumour Proportion Score.
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Corresponding Author
Kallem Sharat Venkat Reddy
Pharm-D, Bharat Institute of Technology
Address: H-no.1-76, Shantinagar, Vanasthalipuram
Hyderabad, Telangana-500070, India
DOI: https://dx.doi.org/10.18535/jmscr/v8i9.35
