Abstract
Background: Gestational trophoblastic disease (GTD) includes a series of disorders that are characterized by an abnormal proliferation of trophoblastic tissue with varying tendency to spontaneous remission, local invasion and metastasis. The incidence of GTD varies greatly in different parts of the world. Hydatidiform mole presents with amenorrhea, painless vaginal bleeding and spontaneous passage of grape-like vesicles, high serum and urinary β human chorionic gonadotrophin (βHCG) levels.
Objective: To study epidemiology & clinical profile of Gestational Trophoblastic Disease and to evaluate its management and outcome.
Material and Methods: A retrospective study was conducted over a period of five years in MDM Hospital, Jodhpur. A total of 39301 pregnancies were recorded during the period of five years. The demographic profile, clinical presentation, management and complications were studied.
Results: There were 60 patients of GTD with an incidence of 1.52 per 1,000 pregnancies. Among these 60 cases, 45 (75%) cases had complete H mole. Most of the patients (63.3%) were in age group of 21-30 years and majority in nulliparous women (38.3%). Majority of the molar pregnancy cases 83.3% cases have been detected in the second trimester. The most common clinical presentation was bleeding per vaginum constituting 58.3% of cases. Majority (85%) of the patients were treated by suction and evacuation.
Conclusion: Gestational Trophoblastic Disease requires early diagnosis, treatment and strict monitoring to be 100% curable. Routine check-up helps to timely management of the GTDs thereby preventing their progression to GTN.
Keywords: Gestational Trophoblastic Disease, Hydatidiform Mole, Molar Pregnancy, Neoplasia, Serum beta HCG.
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Corresponding Author
Dr Vinod
Department of Obstetrics and Gynaecology, MDM Hospital, Dr. S. N. Medical College, Jodhpur, Rajasthan
DOI: https://dx.doi.org/10.18535/jmscr/v8i9.11
