Abstract
Introduction: Autopsy provides an opportunity to uncover the changing patterns of disease in modern era. Chronic Renal Disease is a global health crisis, with an estimated worldwide prevalence of 8 -16%. So the current study is undertaken with the aims to analyze varied spectrum of renal lesions detected on autopsy and to study effect of associated co-morbidities for renal pathology.
Material and Methods: Present retrospective cross sectional study of both Medico-legal and clinical autopsy cases with total of 260 cases was carried out at Tertiary care center during July 2018 to June 2019.Microscopic histopathological examination was done and correlated with clinical details.
Results: We found 105 (40.38%) cases with renal pathologies, while 155 cases (59.61%) showed normal histology, with most commonly affecting 21-30 years of age. Male to female ratio was 1.7:1. Non-glomerular lesions were more common than glomerular.
Conclusion: Present study reveals many renal lesions which produce no functional derangement and are detected for the first time at autopsy.
Keywords: Autopsy, Kidney lesion, Histopathology, Spectrum, Diabetes, Hypertension.
References
- Reddy, KSN &Murty, Om. (2017). The Essentials of Forensic Medicine and Toxicology - 34th Edition by KSN Reddy and OP Murty.
- Jha V, Garcia-Garcia G, Iseki K, et al. Chronic kidney disease: global dimension and perspectives [published correction appears in Lancet. 2013 Jul 20;382(9888):208]. Lancet. 2013;382(9888):260‐272.
- Levey AS, Atkins R, Coresh J, et al. Chronic kidney disease as a global public health problem: approaches and initiatives - a position statement from Kidney Disease Improving Global Outcomes. Kidney Int. 2007;72(3):247‐259.
- Schiffrin EL, Lipman ML, Mann JF. Chronic kidney disease: effects on the cardiovascular system. Circulation. 2007;116(1):85‐97.
- Nagata M, Ninomiya T, Doi Y, et al. Trends in the prevalence of chronic kidney disease and its risk factors in a general Japanese population: the Hisayama Study [published correction appears in Nephrol Dial Transplant. 2010 Dec;25(12):4123-4]. Nephrol Dial Transplant. 2010;25 (8): 2557‐2564.
- Xu J, Murphy SL, Kochanek KD, Arias E. Mortality in the United States, 2015. NCHS Data Brief. 2016;(267):1‐8.
- Wang HE, Muntner P, Chertow GM, Warnock DG. Acute kidney injury and mortality in hospitalized patients. Am J Nephrol. 2012;35(4):349‐355.
- Kurnatowska I, Jędrzejka D, Małyska A, Wągrowska-Danilewicz M, Danilewicz M, Nowicki M. Trends in the incidence of biopsy-proven glomerular diseases in the adult population in central Poland in the years 1990-2010. Kidney Blood Press Res. 2012;35(4):254‐258.
- Zaza G, Bernich P, Lupo A; ‘Triveneto’ Register of Renal Biopsies (TVRRB). Incidence of primary glomerulonephritis in a large North-Eastern Italian area: a 13-year renal biopsy study. Nephrol Dial Transplant. 2013;28(2):367‐372.
- SNSYadav. Histomorphological Study of Kidney Lesions In Autopsy- An Original Eight Year Study. IOSR Journal of Dental and Medical Sciences (IOSR-JDMS), vol.18,no.5,2019,pp 50-54.
- Dr P.S. Mulay, Dr Aanchal Khosla. Kidney Lesions in autopsy:3-year study in a Tertiary Health care. Journal of Medical Sciences And Clinical Research,vol 08 Issue 02 Feb2020
- Amandeep Kaur, Vijay Kumar Bodal, Puneet Garg, Akashdeep Aggarwal. Histopathological Spectrum of Kidney lesions In autopsy- A study of 100 cases. JMSCR Vol.06 Issue 02 Feb 2018
- Utsaet al Histomorphological and immune alteration in autopsied kidneys. Saudi. Med. Jr.2014;35:1331-38.
- Vaneet Kaur Sandhu, Arun Puri and Navtej Singh. Histomorphological Spectrum of Renal Lesion in An Autopsy Study. Annals of Pathology and lab medicine.2017 (4)
- Hailemariam S et al. Renal pathology and premortem clinical presentation of Caucasian patients withs AIDS; An autopsy study from the eraprior to antiretroviral therapy. SwissMed mwkly2001;131:412-17
- Marie E Parrone, Anthony Chang and Kammi J Henriksen. Medical renal disease are frequent but often unrecognized in adult autopsies. Modern pathology (2018)31,365-373
- Kumar V, Abbas AK, Aster JC. Robbins and Cotran Pathologic Basis of Disease, South Asia Edition. Reed Elsevier: New Delhi. 2015.
Corresponding Author
Dr Manjiri G Khade
Assistant Professor, Department of Pathology, GMC, Akola, Maharashtra, India – 444001
DOI: https://dx.doi.org/10.18535/jmscr/v8i6.115
