Abstract
Epidermodysplasia verruciformis (EV) is a rare disorder that is usually transmitted in an autosomal recessive manner, caused by human papillomavirus. It has tendency for malignant transformation, especially squamous cell carcinoma. These patients show a defect in cell-mediated immunity specific toward the causative HPVs that lead to lifelong disease. The defect is usually inherited as autosomal recessive trait and presents clinically with plane warts, pityriasis versicolor like lesions and reddish verrucous plaques. Here we present a case of 15 year boy with complaints of asymptomatic hypopigmented macular lesions and flat wart-like lesions over the face, neck, hands and forearms. Histopathology was suggestive of EV. He was given oral zinc, sunscreen and advised regular follow up.
References
- Yoshida R, Kato T, Kawase M, Honda M, Mitsuishi T. Two sisters reveal autosomal recessive inheritance of epidermodysplasia verruciformis: A case report. BMC Dermatol 2014;14:12.
- Sharma S, Barman KD, Sarkar R, Manjhi M, Garg VK. Efficacy of oral zinc therapy in epidermodysplasia verruciformis with squamous cell carcinoma. Indian Dermatol Online J 2014;5:55‑8.
- Ostrow RS, Manias D, Mitchell AJ, Stawowy L, Faras AJ. Epidermodysplasia verruciformis. A case with primary lymphatic dysplasia, depressed cell-mediated immunity, and Bowen’s disease containing human papilloma 16 DNA. Arch Dermatol 1987;123:1511-6.
- Pfister H. Human papilloma viruses and impaired immunity vs epidermodysplasia verruciformis. Arch Dermatol 1987;123: 1469-70.
- Ramoz N, Rueda LA, Bouadjar B, Montoya LS, Orth G, Favre M. Mutations in two adjacent novel genes are associated with epidermodysplasia verruciformis. Nat Genet 2002;32:579‑81.
- Castro‑Pérez GA, Sorin I, Bravo AI, Mazzuoccolo LD. Acquired epidermodysplasia verruciformis in a patient with congenital HIV infection. Actas Dermosifiliogr2013;104:731‑3
- Rodríguez L, Contreras R, Di Martino Ortiz B, de Lezcano LB. Acquired epidermodysplasia verruciformis in an HIV positive child. Report of a case. Our Dermatol Online 2015;6:32‑5.
- Roncalli de Oliveira W, Neto CF, Rady PL, Tyring SK. Seborrheic Keratosis‑like lesions in patients with epidermodysplasia verruciformis. J Dermatol 2003;30:48‑53.
- Gül U, Kiliç A, Gönül M, Cakmak SK, Bayis SS. Clinical aspects of epidermodysplasia verruciformis and review of the literature. Int J Dermatol 2007;46: 1069‑7.
- Vohra S, Sharma NL, Shanker V, Mahajan VK, Jindal N. Autosomal dominant epidermodysplasia verruciformis: A clinicotherapeutic experience in two cases. Indian J Dermatol Venereol Leprol 2010;76:557‑61.
- García-Río I, Garcia-F-Villalta MJ, Daudén E, Fraga J, García-Díez A. Epidermodysplasia verruciformis-like lesions in a patient with systemic lupus erythematosus. Acta Derm Venereol 2003;83:229-30.
Corresponding Author
Ravinder Singh
Medical Officer Dermatology Dr RKGMC Hamirpur HP
DOI: https://dx.doi.org/10.18535/jmscr/v8i6.77
