Abstract
Background: Preoperative medication has a vital role in anesthesia. In this study, Gabapentin and Clonidine are evaluated in the clinical efficacy of oral premedication in reducing the postoperative pain and opioid consumption in patients undergoing gastrectomyas these medications possess anxiolytic, analgesic, and anticonvulsant properties..
Methodology: Prospective, randomized, double blind, placebo controlled study was conducted on ninety patients of ASA (American Society of Anesthesiologists)Grade I and II of age group 45–65 years, allocated to one of the three groups of thirty patients each. Group I received Tab Gabapentin 600mg mg, Group II received Clonidine 100 μg and Group III received placebo at 10:00 pm, the night before and 1 h before the surgery. Parameters including sedation scores, post operative pain, opioid consumption and various side effects were assessed.
Results: Demographic variables were comparable. The VAS pain scores at measured times were significantly lower in the gabapentin group as compared to clonidine and placebo group. The post-operative opioid consumption in Gabapentin group was significantly less than Clonidine and placebo groups. There was no significant difference between the groups regarding the postoperative complications. Number of patients required > one dose of rescue analgesic were highest in the placebo group as compared to group I and group II.
Conclusion: Our study concluded that administration of 1200mg of gabapentin or 200μg clonidine preoperatively significantly reduces VAS score and opioid consumption when compared to placebo in patients undergoing gastrectomy. Also Gabapentin was more effective than clonidine in reducing postoperative pain and morphine use for analgesia.
Keywords: Gabapentin; Clonidine; Postoperative VAS; Gastrectomy; Analgesia.
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Corresponding Author
Irfan Andleeb Gul
Senior Resident, Department of Orthopaedics, Govt. Medical College, Srinagar, India
DOI: https://dx.doi.org/10.18535/jmscr/v8i6.67
