Abstract
Purpose: To analyze the clinicopathological characteristics and the outcome of various treatment modalities used in management of lung cancer in females.
Methods: This was a retro-prospective study in which female patients with histological confirmed lung cancer who were registered at Regional Cancer Centre of Sher-i-Kashmir Institute of Medical Sciences, Srinagar between 2008 to 2014 were enrolled. Patient characteristics with regard to age, clinical presentation, locality, investigations, pathological characters and outcome of various treatment modalities were studied in detail. Data was compared using Pearson chi-square and Fischer’s exact test. P value <0.05 was considered to be statistically significant. SPSS version 20 was used for analyzing the data.
Results: A total of 298 patients were enrolled and 167 received treatment. Most patients were in the elderly age group (32.9%) and were from Srinagar district (29.9%). Dry cough was present in 71.4% of patients at presentation. Most common diagnostic modality used was bronchoscopy (58.05%). Squamous cell ca was most common histology (41.5%). Most (63.4%) patients were non smokers. 54.4% of patients had stage 4 at presentation. Chemotherapy alone was the most frequently used treatment modality (33.5%). Only 96 were available for response evaluation. During follow up, 3.12% had local failure and 27.08% had distant metastasis. Overall 1,2,3 and 6 year survival rates were 72.2%, 21.9%, 4.5% and 1.3% respectively. Triple modality treatment had highest survival rates followed by chemoradiation.
Conclusion: Delayed diagnosis and advanced disease were responsible for poor outcome. Early diagnosis and treatment and combined modality of treatment can improve survival.
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Corresponding Author
Dr Isha Puri
Registrar Department of Radiation Oncology, Government Medical College Jammu, Pin-180001 (J&K) India
DOI: https://dx.doi.org/10.18535/jmscr/v8i6.64
