Abstract
Background: Prematurity is still a major problem for health care services throughout the world. Respiratory distress syndrome (RDS) is the primary cause of morbidity and mortality in preterm newborns. Frequency of morbidity and mortality in infants treated with antenatal steroid is less than those delivered without this therapy. Many pregnant females deliver before term or 37 weeks; hence these may be advised antenatal corticosteroid therapy without creating significant maternal or fetal side effects.
Method: It was an observational study conducted in the department of obstetrics and gynecology IGMC Shimla for 1 year duration.
Results: The study sample of 244 was divided into two groups on the basis of exposure to antenatal corticosteroids. RDS was reported 57 cases (preterm neonates) in the study. It was seen in41 out of 165 cases of steroids uncovered group and 16 cases out of 79of steroid covered group. Mortality among steroid uncovered group was seen in 71 preterm neonates out of 165 as compared to 10 neonatal deaths out of 79 in steroid covered group.
Conclusion: Mortality in the infants treated with antenatal corticosteroid is significantly less than the group of preterm newborns delivered without this therapy.
References
- Shahzad F, Umar N. Impact of antenatal corticosteroids on frequency and mortality due to respiratory distress syndrome in preterm neonates. J Ayub Med Coll Abbottabad.2016;28(4):698-701.
- Grqic O, Matijevic R. Dilemmaas about the Antenatal use of corticosteroids for prevention of neonatal morbidity and mortality. Acta Med Croatica 2005;59(2):129–35.
- Bonanno C, Wapner RJ. Antenatal corticosteroid treatment: What’s happened since Drs Liggins and Howie? Am J ObstetGynecol 2009;200(4):448–57.
- Crowley P. Prophylactic corticosteroids for preterm delivery (Cochrane Review). Cochrane Libr 1999;1.
- Antenatal corticosteroids to reduce to reduce neonatal morbidity and mortality. Green-top guideline No. 7, October 2010; p: 3,4.
- Murphy KE, Hannah ME, Wilan AR et al. Multiple courses of antenatal corticosteroids for preterm birth : a randomised controlled trial. Lancet. 2008;372(9656):2143-51.
- Bennet P. preterm labors. In: Edmonds DK, Dewhurst J, editors. Dewhurst’s textbook of obstetrics & gynaecology. 7th ed. Malden, Mass: Blackwell Pub; 2007. p.177–8.
- Whitsett JA, Pryhuber GS, Rice WR, Warner BB, Wert SE. Acute respiratory disorders. In: Avery GB, Fletcher MA, MacDonald MG, editors. Neonatology: Pathophysiology and Management of the Newborn. 4th ed. Philadelphia, PA: JB Lippincott Company; 1994. p.429–52.
- Shirazi H, Riaz S, Mahmood RA. Morbidity and Mortality Pattern of Newly Born Babies in a Teaching Hospital. J Rawal Med Coll 2015;19(3):204–8.
- Klinger G, Koren G. Controversies in antenatal corticosteroid treatment. Can Fam Physician 2000;46:1571–3.
- Effect of corticosteroids for foetal maturation on perinatal outcomes. NIH Consens Statement 1994;12(2):1–24.
- Wang K, Chen CY, Chen CP. Effects of Antenatal Corticosteroids in Preterm Delivery. Taiwan J Obstet Gynaecol 2004;43(4):193–8.
- Mwansa-Kambafwile J, Cousens S, Hansen T, Lawn JE. Antenatal steroids in preterm labour for the prevention of neonatal deaths due to complications of preterm birth. Int J Epidemiol 2010;39(Suppl 1):i122–33.
- Roberts D, Dalziel S. Antenatal corticosteroids for accelerating foetal lung maturation for women at risk of preterm birth. Cochrane Database Syst Rev 2006;3:CD004454.
- Singh U, Singh N, Seth S. A prospective analysis of etiology and outcome of preterm labor. J ObstetGynecol India 2007;57(1):48-52.
- Riskin-Mashiah, S, Riskin A, Bader D, Kugelman A,Boyko V, Lerner-Geva L et al. Antenatal corticosteroid treatment in singleton, small-for-gestational-age infants born at 24– 31 weeks’ gestation: a population-based study. BJOG 2016;123: 1779-86.
Corresponding Author
Dr Sapna Berry
VPO Bathri Tehsil Dalhousie, District Chamba Himachal Pradesh, India
DOI: https://dx.doi.org/10.18535/jmscr/v8i6.61
