Abstract
Objectives: The rising trend of extra-pulmonary tuberculosis among HIV positive patients, study of the proportion of HIV seropositive among patients with tubercular cervical lymphadenitis, variations in clinical presentation, diagnostic yield of FNAC, microbiological findings and cytomorphological pattern of cervical lymph nodes in HIV positives and negatives gains importance.
Methodology: In all, 110 patients, considered as tubercular cervical lymphadenitis cases, were screened by chest radiography, tuberculin test (MT), fine needle aspiration cytology (FNAC) and smear microscopy for AFB of aspirate lymph nodes. All these patients were also tested for HIV sero positivity by two different ETLISA tests, repeated at least twice.
Results: 85 confirmed tuberculosis patients, 16 (18.8%) had HIV seropositive, in which 9 of (56.2%) had demonstrable AFB in FNAC cervical node aspirate; only one HIV negative patient (1.4%) had positive smear microscopy for AFB. Among the 16 HIV positive patients, typical granuloma and/or caseative necrosis were found in 10 patients (62.5%) and atypical granuloma with numerous macrophages features were found in the remaining 6 patients (37.5%).
Conclusion: The high prevalence of HIV seropositivity (18.8%) among the 85 tubercular cervical lymphadenitis patients suggests a rising trend of HIV infection in pockets of rural western Rajasthan Indian population. Disseminated tuberculosis and atypical cytomorphological features were found in tubercular lymph nodes in our study suggest an advanced stage of HIV disease in our population group.
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Corresponding Author
Dr Mangilal Choudhary
Assistant Professor, Central lab Pathology
Govt. Medical College & Bangur Hospital Pali (Rajasthan), India
DOI: https://dx.doi.org/10.18535/jmscr/v8i4.68
