Abstract
Background: Colorectal cancers are the second most common cause of death in the UK. It is usually caused due to mutations of APC, K-ras, p53 genes. Patients present more commonly with bleeding per rectum or obstructive symptoms. Colonoscopy is the investigation of choice. Staging is by spiral CT. The aim of the study is to calculate the age-wise incidence, common presenting symptoms, and treatment strategies employed in our setup.
Material and Methods: A retrospective study was conducted on 30 cases of colorectal cancer in the Department of General Surgery, King George Hospital, Visakhapatnam, from June 2018 to June 2019. Patients presenting with symptoms suggestive of colorectal cancer were admitted, investigated using routine investigations, colonoscopy, and CT scan, and operated during this period. Factors studied were incidence, presenting complaints, and treatment options.
Results: Twenty cases were between the age group 45-60, 8 cases were above 60 years, and 2 cases between the age group 40-45. Twenty-five cases presented with bleeding per rectum, anemia, and 5 cases presented with increased frequency and pain during defecation. The most common histology was moderately differentiated adenocarcinoma. All the patients underwent resection of the primary tumor with regional lymphadenectomy.
Conclusion: The incidence of colorectal cancer has risen. The risk of incidence is more in the age group 45-60 years with bleeding per rectum as the common presenting complaint. Increasing awareness regarding the risk factors and symptoms is needed for early detection. Early diagnosis with prompt screening techniques helps to reduce the mortality rate.
References
- Munakata, S., Murai, Y., Koiuzumi, A., Kato, H., Yamamoto, R., Ueda, S., … Sato, K. (2018). Long-term outcomes of colorectal cancer patients with and without malignant large-bowel obstruction. Colorectal Cancer, 7(2), CRC04. doi:10.2217/crc-2018-0001.
- An overview of 25 years of incidence, treatment and outcome of colorectal cancer patients.Nelleke P.M. Brouwer, 1 Amanda C.R.K. Bos, 2 Valery E.P.P. Lemmens, 2 , 3 Pieter J. Tanis, 4 Niek Hugen, 1Iris D. Nagtegaal, 5 Johannes H.W. de Wilt, 1 and Rob H.A. Verhoeven 1 ,
- Lemmens V, van Steenbergen L, Janssen‐Heijnen M, et al. Trends in colorectal cancer in the south of The Netherlands 1975‐2007: rectal cancer survival levels with colon cancer survival. Acta Oncol2010;49:784–96. [PubMed] [Google Scholar]
- Toes‐Zoutendijk E, van Leerdam ME, Dekker E, et al. Real‐time monitoring of results during first year of dutch colorectal cancer screening program and optimiza-tion by altering fecal immunochemical test cut‐off levels. Gastroenterology 2016;154 (4):767–777. [PubMed] [Google Scholar]
- Bokkerink GM, Buijs EF, de Ruijter W, et al. Improved quality of care for patients undergoing an abdominoperineal excision for rectal cancer. Eur J Surg Oncol 2015; 41:201–7. [PubMed] [Google Scholar]
- Bonjer HJ, Deijen CL, Haglind E. A randomized trial of laparoscopic versus open surgery for rectal cancer. N Engl J Med 2015;373:194. [PubMed] [Google Scholar]
- Kapiteijn E, Marijnen CA, Nagtegaal ID, et al. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med 2001;345:638–46. [PubMed] [Google Scholar]
- Buunen M, Veldkamp R, Hop WC, et al. Survival after laparoscopic surgery versus open surgery for colon cancer: long‐term outcome of a randomised clinical trial. Lancet Oncol 2009;10:44–52. [PubMed] [Google Scholar]
- Jobsen J, Aarts MJ, Siesling S, et al. Use of primary radiotherapy for rectal cancer in The Netherlands between 1997 and 2008: a population‐based study. Clin Oncol (R Coll Radiol) 2012;24:e1–8. [PubMed] [Google Scholar]
- Smith JJ, Garcia‐Aguilar J. Advances and challenges in treatment of locally advanced rectal cancer. J Clin Oncol 2015;33:1797–808. [PMC free article] [PubMed] [Google Scholar]
- Andre T, Boni C, Navarro M, et al. Improved overall survival with oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment in stage II or III colon cancer in the MOSAIC trial. J Clin Oncol 2009; 27:3109–16. [PubMed] [Google Scholar]
- Verhoeff SR, van Erning FN, Lemmens VE, et al. Adjuvant chemotherapy is not associated with improved Survival for all high‐risk factors in stage II colon cancer. Int J Cancer 2016;139:187–93. [PubMed] [Google Scholar].
- van der Pool A, Damhuis RA, IJzermans JN, et al. Trends in incidence, treatment and Survival of patients with stage IV colorectal cancer: a population‐based series. Color Dis 2012;14:56–61. [PubMed] [Google Scholar].
Corresponding Author
Simhadri Uday Kiran
Post Graduate, General Surgery