Abstract
Introduction: Present work was aimed to study the correlation of hs-CRP with left ventricular function in patients of NSTEMI, STEMI and unstable angina. This study was carried out in 120 patients of acute coronary syndrome, presenting to Guru Nanak Dev Hospital attached to Government Medical College, Amritsar.
Material and Methods: Present work is a prospective observational study to determine correlation between plasma hs-CRP levels and outcome in patients with acute coronary syndrome. The data was collected from the patients and recorded in a prepared Case Report Form. Demographic details, medical history, information on exercise, diet, substance use, and hospitalization details was collected. After relevant history and thorough clinical examination, height, weight and BMI were measured. Hs-CRP was measured in patients and echocardiography was performed.
Results: In the present study, the data showcases the relationship between hs- CRP and various echocardiographic parameters in patients with acute coronary syndrome. Observations of the present study shows the correlation between the mean hs-CRP and ejection fraction of individuals of NSTEMI, STEMI and Unstable angina.
Conclusions: The data concludes that hs-CRP is more closely related to LV function as assessed by ejection fraction. As our data demonstrated a significant correlation between high hs-CRP and reduced EF, increased hs- CRP may be a marker of LV dysfunction.
Keywords: hs-CRP, Acute coronary syndrome, Unstable angina, STEMI, NSTEMI.
References
- Libby P. Current Concepts of the Pathogenesis of the Acute Coronary Syndromes. Circulation. 2001;104(3):365-72.
- Ross R. Atherosclerosis-an inflammatory disease. N Engl J Med. 1999;340(2):115-26.
- Calabrò P, Golia E, Yeh ET. CRP and the risk of atherosclerotic events. Semin Immunopathol 2009;31(1):79-94.
- Blake GJ, Ridker PM. Novel clinical markers of vascular wall inflammation. Circ Res 2001; 89:763-71
- Calabro P, Willerson JT, Yeh ET. Inflammatory cytokines stimulated C- reactive protein production by human coronary artery smooth muscle cells. Circulation. 2003;108(16):1930-32.
- Silva D, Pais de Lacerda A. High- sensitivity C-reactive protein as a biomarker of risk in coronary artery disease. Rev Port Cardiol 2012; 31(11):733-45.
- Sheikh AS, Yahya S, Sheikh NS, Sheikh AA. C-reactive protein as a predictor of adverse outcome in patients with acute coronary syndrome. Heart Views. 2012;13:7–12.
- Mach F, Lovies C, Gaspoz JM, Unger PF, Bouilli M, Urban P et al. C- reactive protein as a marker for acute coronary syndromes. Eur Heart J. 1997;18:897–902.
- Cavusoglu Y, Gorenek B, Alpsoy S, Unalir A, Ata N, Timuralp B. Evaluation of C-reactive protein, fibrinogen and anti-thrombin III as risk factors for coronary artery disease. Isr Med Assoc J. 2001;3:36–8.
- Tomoda H, Aoki N. Prognostic value of C-reactive protein levels within six hours after the onset of acute myocardial infarction. Am Heart J. 2000;140:324–8.
- Beck B, Weintraub WS, Alexander R. Elevation of C-reactive protein in “active” coronary artery disease. Am J Cardiol. 1990;65:168–72.
- He L, Tang X, Ling W, Chen W, Chen Y. Early C-reactiveprotein in the prediction of long-term outcomes after acutecoronary syndromes: a meta-analysis of longitudinal studies. Heart. 2010;96:339-46.
- Liuzzo G, Biasucci LM, Gallimore JR, Grillo RL, Rebuzzi AG, Pepys MB et al. The prognostic value of C-reactive protein and serum amyloid A protein in severe unstable angina. N Engl J Med. 1994;331:417–24.
- Liuzzo G, Biasucci LM, Rebuzzi AG, Gallimore JR, Caligiuri G, Lanza GA et al. Plasma protein acute phase response in unstable angina is not induced by ischemic injury. Circulation. 1996;94:2372–80
- Biasucci LM, Vitelli A, Liuzzo G, Altamura S, Caligiuri G, Monaco C et al. Elevated levels of interleukin-6 in unstable angina. Circulation. 1996; 94:874.
Corresponding Author
Dr Aman Deep Goel
Department of Medicine, Government Medical College, Amritsar-143001, India