Abstract
Background: Surgical site infections (SSIs) are a common cause of health-related infection and are associated with extended hospital stays and increased costs. The incidence of surgical site infections is affected by factors such as bacterial inoculation and virulence, host defenses, preoperative treatment and intraoperative management. Antimicrobial prophylaxis has been recognized as a standard procedure to eliminate postoperative risks of clinical practice due to infections. Our research was designed to determine the impact of prophylactic antibiotics on patient's elective postoperative wound and to analyze the result.
Methods: A prospective study that includes 200 patients admitted to the Department of Surgery at Dr RML Hospital New Delhi from March to August 2019 undergoing elective surgery was conducted. The research involved patients who underwent elective surgery. Preoperatively, ceftriaxone was used 30 minutes before incision and its impact on postoperative wound infection was studied.
Results: In our sample, we had 200 cases mainly males of 20-40 years of maximum age range. After administering antimicrobial prophylaxis, 07% of the maximum 200 patients experienced SSI.
Conclusions: A single dose of Ceftriaxone prophylaxis antibiotics is effective in preventing uncomplicated surgical site infection in an elective situation assuming an uncomplicated procedure.
References
- Zumla A. Mandell, Douglas, and Bennett's principles and practice of infectiou Diseases. 2010;10(5):303
- Kirkland KB, Briggs JP, Trivette SL, of surgicalsite infections in the 1990s: Attributable mortality, excess length of hospitalization, and extra costs. Infect Control Hosp Epidem
- Berríos-Torres SI, Umscheid CA, Bratzler DW, et al. Centers for Disease Control and Prevention Guideline for the Prevention of Surgical Site Infection, 2017. JAMA Surg 2017; 152:784
- Global guidelines for the prevention of surgical site infection.World Health Organization 2016 https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0095752/pdf/PubMedHealth_PMH0095752.pdf (Accessed on September 19, 2017).
- Miles AA, Miles EM, Burke J. The value and duration of defence reactions of the skin to the primary lodgement of bacteria. Br J Exp Pathol
- Burke JF. The effective period of preventive antibiotic action in experimental in Surgery.1961; 50: 161-168.
- Ortega GM, Marti-Bonmati E, Guevara SJ, Alteration of vancomycin pharmacokinetics during cardiopulmonary bypass in patients undergoing cardiac surgery. Am J Health Syst Pharm
- Bratzler DW, Houck PM. Antimicrobial prophylaxis for surgery: An advisory statement from the National Surgical Infection Prevention Project. 2004; 38:1706-1715.
- Gilbert DN, Moellering RC Jr, Eliopoulos GM, The Sanford Guide to Anti Sperryville, VA: Antimicrobial Therapy Inc.; 2008.
- Antimicrobial prophylaxis in surgery [SIGN publication No. 45]. Scottish Intercollegiate Guideline Network Website. http://www.sign.ac.uk/guidelines/fulltext/45/index.html. Accessed Au
- Polk HC Jr, Christmas B. Prophylactic antibiotics in surgery and surgical wound infections.66:105-111.
- Bratzler DW, Hunt DR. The surgical infection prevention and surgical care improvement projects: National initiatives to im having surgery. Clin Infect Dis
- Steinberg JP, Braun BI, Hellinger WC, antimicrobial prophylaxis and the risk of surgical site infections: Results from the Trial to Reduce Antimicrobial Prophylaxis Errors (TRAPE). 2009.
- Olson MM, Lee JT Jr. Continuous, 10-year wound infection surveillance. Results, advantages, and unanswered questions. Arch Surg 1990; 125:794-803.
- Silvia Nunes Szente Fonseca, Soˆnia Regina Melon Kunzle, Maria Jose´ Junqueira, Renata Teodoro Nascimento, Jose´ Ivan de Andrade, Anna S. Levin.Implementing 1-Dose Antibiotic Prophylaxis for Prevention of Surgical Site Infection.Arch Surg. 2006;141:1109-1113.
Corresponding Author
Dr Md Whhaj
Senior Resident DMCH