Abstract

Background: Fatty liver disease in absence of alcohol abuse is now emerging as a major health burden in the world. It represents the hepatic manifestation of the metabolic syndrome, a variably defined aggregate of disorders related to obesity, insulin resistance, diabetes mellitus type 2, hypertension, and hyperlipdemia.

Methods: This prospective observational study was conducted in 65 patients with ultrasonographic findings of fatty liver disease either from OPD or from IPD basis of department of medicine, M.Y. Hospital, Indore.

Results: Out of 65 patients, 54(83%) patients had the fibroscan score less than 7  i.e. patients had median stiffness of the liver less than the cut off value, while only 11(17%) patients i.e. patients had median stiffness of the liver more than its cut off value. We found that only 12(18%) patients had adiponectin levels less than its normal value while 53(82%) patients had adiponectin levels within the normal range. Various biochemical parameters of the patients were compared across the gender where it was found that variable like triglycerides, ALT, AST, and adiponectin levels were approximately same across the gender without any significance (P value 0.533, 0.342, 0.167, and 0.967 respectively) but cholesterol values across the gender was significant (P value=0.000).

Conclusions: In Indian population also, NAFLD has association with its risk factors like obesity, larger neck circumference, higher waist hip ratio, and triglyceride levels. Low adiponectin levels association to the NAFLD found to be less in Indian population. Further study needed in large group of subjects from India.

Keywords: Adiponectin, cholesterol, non alcoholic fatty liver disease, triglycerides.