Abstract
Background: Chronic Kidney Disease (CKD) is a worldwide health problem and one of the major health burden in developing countries like India. Dyslipidemia due to alteration in lipoprotein metabolism was considered as a complication of end stage renal disease (ESRD) but these changes can be present in early stages of CKD. Over the last decade it is established that Cardio-Vascular Disease is the major cause of mortality with mild to moderate and ESRD. The present study focused on finding an approximate prevalence of dyslipidemia,type of alteration in lipid fractions in non diabetic CKD populations and the association with staging.
Methods: The study was conducted in VIMSAR, Burla during NOV 2017 to OCT 2019 with an objective to study the lipid profile in non diabetic CKD patients. Patients with CKD admitted to Dept. of Gen. Medicine And Nephrology who had given consent for the study were the source of data. History, clinical examination with supporting biochemical and radiological evidences of 150 cases were taken for diagnosis of CKD. 75 numbers of age and sex matched healthy indivisuals were taken as control. MDRD equation was used to calculate eGFR. Staging of CKD is as per KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management Of Chronic Kidney Disease.
Results: Among a total of 150 patients with mean age of 52.92 ± 11.41, the prevalence of dyslipidemia in CKD was found to be about 78.67%. There is significant increase in serum TG with the increase in severity of the disease. Most common abnormality is fall in the serum HDL cholesterol in 59.33% of patients followed by a rise in serum triglyceride concentration 51.33% in patients suffering from CKD.
Conclusion: The high prevalence of lipid abnormalities in CKD may accelerate the progression of Cardio Vascular Disease and increase the mortality of patients. Hence it is worthwhile to early diagnose and manage accordingly to reduce morbidity and mortality.
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Corresponding Author
Dr Soumya Ranjan Patra
DOI: https://dx.doi.org/10.18535/jmscr/v8i3.98
