Abstract
Introduction
Hypertension is one of the most important cardiovascular risk factors with very high prevalence. With uncontrolled hypertension there is high risk of myocardial infarction, stroke, atherosclerosis and renal failure.1 As per the Registrar General of India (2017), CVD was the largest cause of deaths in males (33.8%) as well as females (34.3%) and out of that death due to hypertension happened in 14.2% of males and 16.2% of females.2 The number of hypertensive patients in India is expected to double from 118.2 million in 2000 to 213.5 million by 2025. Henceforth India would be labelled as the “hypertension capital of the world”.3
International guidelines suggests that in the general population, pharmacologic treatment should be initiated when blood pressure is 150/90 mm Hg or higher in adults 60 years and older, or 140/90 mm Hg or higher in adults younger than 60 years.4 Successful treatment of hypertension leads to significant reduction of comorbidity and death.5,6,7 According to the Eighth Joint National Committee (JNC 8), medications in the management of hypertension in adults, includes four major groups of drug. Among these, angiotensin II-receptor blockers (ARBs) have similar or greater efficacy compared with other classes of hypertensive agents but are much more tolerable.8,9,10 ARBs have no negative metabolic effects and they cause no accumulation of bradykinin. They also have an ability to activate the angiotensin II type 2 (AT2) receptors, which causes vasodilatation in the small vessels and presumably leads to additional cardiac and renal protection.
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Corresponding Author
Dr Priti Das
Associate Professor, Department of Pharmacology, S.C.B.MCH, Cuttack, India
DOI: https://dx.doi.org/10.18535/jmscr/v8i3.97
