Abstract

Objective: In this study our main goal is to evaluate the management and outcome of Peripheral ulcerative keratitis (PUK) in Bangladesh.

Method: This observational study was done in the in the National Institute of Ophthalmology & Hospital from October 2018 to October 2019. A total of 100 consecutive patients were included. The diagnosis PUK was made on the basis of presence of crescent-shaped destructive inflammation within at least 2 mm of limbus associated with epithelial defect, stromal inflammatory cells and possibly stromal degradation.

Results: during the study,the mean random blood sugar was 11.4±5.4 mg/dl in and 9.1±4.1 mg/dl in patients.35% patients had blurred vision, followed by 25% had increased sensitivity to bright light, 40% had a sensation of a foreign object trapped in the eye. significant visual improvement was noted in severe cases (p=0.001) and all those cases in which surgery was done after medical failure (p=0.012).For severe diseases mean time to healing in the cases which were treated medically was 33.78±11.67 days.

Conclusion: From our study we can conclude that, patients with PUK require thorough ocular and systemic investigations to detect the aetiology on which the treatment is based. Surgical intervention in perforated cases had good visual prognosis and anatomical success. In spite of complete resolution, continued, possibly lifelong, follow-up of cases is necessary since relapse may occur.

Keywords: Peripheral ulcerative keratitis (PUK), crescent-shaped destructive inflammation, ocular and systemic pattern.