Abstract
Introduction: Cardiovascular disease is the leading cause of disability adjusted life years in developed and developing countries. Traditional cardiovascular risk factors such as obesity, hypertension and disturbances of glucose and lipid metabolism are commonly clustered and insulin resistance has been considered a relevant pathophysiological link. However, a number of cardiovascular events occur in absence of these risk factors indicating that there might be a substantial need for identification of these novel factors.
Adipose tissue secretes adiponectin which participates in energy homeostasis and enhances insulin sensitivity. An inverse association of adiponectinemia with obesity, insulin resistance, inflammation, type 2 diabetes and atherosclerosis has been reported. Adiponectin has been associated with carotid intima medial thickness(CIMT), mainly in high cardiovascular risk population
Therefore, we performed this study to assess the association of adiponectin with CIMT in Indian subjects without diabetes or cardiovascular disease
Material and Method: We conducted a cross sectional observational study at Safdarjung hospital.
Results: Our study proved that adiponectin can be used as marker of subclinical atherosclerosis in non diabetic patients. There is an inverse correlation of serum adiponectin with CIMT (p <0.001). However, we did not observe any correlation between serum adiponectin with visceral body fat and BMI.
Summary: Hence, we can say that as the level of serum adiponectin decreases CIMT increases and vice versa. Therefore serum adiponectin can be used as the marker of subclinical atherosclerosis.
References
- Murray CJ, Barber RM, Foreman KJ, Abbasoglu Ozgoren A, Abd-Allah F, Abera SF, et al. Global, regional, and national disability adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990-2013: quantifying the epidemiological transition. Lancet. Epub ahead of print 26 August 2015. DOI:10.1016/S0140-6736(15) 1340-X
- Khot UN, Khot MB, Bajzer CT, Sapp SK, Ohman EM, Brener SJ,. et al. Prevalance of conventional risk factors in patients with coronary heart disease. JAMA 2003; 290:898-904
- Hlatky MA, Greenland P, Arnett DK, Ballantyne CM, Criqui MH, Elkind MS et al. Criteria for evaluation of novel markers of cardiovascular risk: A scientific statement from the American Heart Association. Circulation 2009,119: 2048-2416
- Lindberg S, Jensen JS, Bjerre M, Pedersen SH, Frystyk J, Flyvbjerg A et al. Adiponectin, type 2 diabetes and cardiovascular risk. Ear J Prev Cardiol 2015; 22:276-283
- Maahs DM, Ogden LG, Kinney GL, et al. Low plasma adiponectin levels predict progression of coronary artery calcification. Circulation 2005;111: 747-753
- Dullart RPF, Vries R, Tol A and Wim J Sluiter. Lower plasma adiponectin is a marker of increase intima media thickness associated with type 2 Diabetes mellitus and with male gender. Eur J Endocrinol 2007; 156: 387-394
- Stein JH, Korcarz CE, Hurst RT, Lonn E, Kendall CB, Mohler ER, et al. use of carotid ultrasound to identify subclinical vascular disease and evaluate cardiovascular disease risk: A consensus Statement from the American Society of Echocardiography Carotid Intima Media Thickness Task Force endorsed by the society for Vascular Medicine. J Am Soc Echocardiogr 2007;21:93-111.
- Santos IS, Alencar AP, Rundek T et al. Low impact of traditional risk factors on carotid intima medial thickness: The ELSA-Brasil cohort. Arterioselerthromb Vasc Biol 2015; 35:2054-2059.
- Bianca de Almeida-Pititto, Fernando Flexa Ribeiro-Filho, Marcio Sommer Bittencourt, Paulo A. Lotufo, Isabela Bensenor, and Sandra R. G. Novel markers of cardiometabolic risk are associated with plasma glucose within non diabetic range. The Brazilian Longitudinal Study of Adult Health- ELSA-Brasil. Diabetes Res Clin Pract 2015; 109: 110-116.
- Santos IS, Bittencourt MS, Oliveira IR, Souza AG, Meireles DP, Rundek T et al. Carotid intima medial thickness value distribution in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil): Atherosclerosis 2014;237:227-235.
Corresponding Author
Dr Jyoti Verma
Department of Medicine, VMMC AND SJH
DOI: https://dx.doi.org/10.18535/jmscr/v8i3.08
