Abstract
Metabolic syndrome is increasingly recognised as emerging threats to health of human race. Thyroid hormones up regulate metabolic pathways relevant to resting energy expenditure. Obesity causes alteration in thyroid function tests. We compared the thyroid profiles of individuals with and without Metabolic Syndrome and assessed the possibility of obesity influencing the results. This is a cross sectional study which includes 200 patients above the age of 18 years attending the outpatient department of our institution from January 2015 to August 2016. They were divided into four groups where group 1 consists of patients with Metabolic syndrome and obesity, group 2 with Metabolic Syndrome without obesity, group 3 without Metabolic syndrome but obese and group 4 without Metabolic syndrome and non obese. The NCEP ATP III criteria was used for assessing Metabolic syndrome and revised consensus guidelines for Asian Indians was chosen to determine the Body Mass Index (BMI) for obesity. TSH, T4, T3 were measured as indicators of thyroid function. The difference in mean TSH levels between individuals with Metabolic Syndrome (3.84 ± 2.44uIU/L) and without Metabolic Syndrome (2.10±1.70uIU/L) was statistically significant (p = £ 0.05) while the mean T4 and T3 levels were comparable. Amongst individuals with metabolic syndrome ,difference of mean TSH between obese and non-obese group was not significant (p=0.984). Individuals with Metabolic syndrome have a higher TSH level but normal T3 and T4 levels. This rise in TSH is independent of obesity.
Keywords: Metabolic syndrome, Thyroid profile.
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Corresponding Author
Dr Amit Sarkar
Burdwan Medical College and Hospital, P.O. Burdwan, Pin – 713104, District – East Burdwan, West Bengal, India
DOI: https://dx.doi.org/10.18535/jmscr/v8i3.04
