Title: A Clinical Study of Hypoxic Ischemic Encephalopathy in Relation to Perinatal Asphyxia in Newborns Admitted in King George Hospital, Visakhapatnam
Authors: Dr Rajasri Jalla, Dr A.Suryabharathi, Dr P. Rakesh
DOI: https://dx.doi.org/10.18535/jmscr/v8i1.129
Abstract
Background: Central Nervous System Dysfunction (Neonatal Encephalopathy) associated with Perinatal Asphyxia is called Hypoxic Ischemic Encephalopathy. Perinatal Asphyxia contributes significantly to Neonatal Morbidity and Mortality. The main aim of the study is to study the clinical profile and to assess the immediate outcome in asphyxiated newborns.
Materials and Methods: A prospective clinical study of 70 term Newborns with Perinatal Asphyxia admitted in NICU KGH from May 2018 to April 2019. Neurological assessment of these neonates was performed and stage of encephalopathy assessed. The relationship between severity of Asphyxia and severity of HIE was studied. Evaluation of other organ systems (Renal, Cardiac, Pulmonary, Git) was performed. Term asphyxiated newborns (inborn and outborn) referred to NICU, KGH were included in this study. Newborns with Congenital malformations, congenital neuromuscular diseases and syndromic babies were excluded from the study.
Results: HIE occurred in 60% of asphyxiated newborns. 54.7% of them had stage I HIE and 28.6% had stage II HIE and 16.7% had stage III HIE. There was significant association between severity of perinatal asphyxia and severity of HIE.
Conclusions: Significant proportion of neonates develop HIE following asphyxia insult. Most of them developed HIE stage-I encephalopathy. As the APGAR score decreases the severity of HIE increases. Following perinatal asphyxia most neonates developed at least one organ dysfunction other than CNS. Kidney is the most frequently involved organ.
