Abstract
Background: Receptor status assessment is not routinely carried out in patients of breast cancer in the Indian subcontinent. Limited data is available on histological and receptor status in Indian patients. In this study receptor status has been correlated with morphological prognostic parameters.
Objective: To analyze receptor status and its correlation with morphological prognostic parameters in Indian females.
Methods: 50 mastectomy specimens of breast carcinoma were received in the department of pathology at Geetanjali medical college and hospital, Udaipur, Rajasthan, India. All the 50 cases were subjected for ER, PR, HER 2 Neu receptor study.
Result: 64% patients diagnosed with breast cancer were 50 years or younger in age. 94% patients were diagnosed as Invasive ductal carcinoma whereas 6 % patients were diagnosed with tubular and tubulobular carcinoma. Only 4% cases were ER/ PR/ HER 2 Neu positive and 16% cases were triple negative indicating poor prognosis.
Keywords: Breast cancer, Invasive ductal carcinoma (IDC), Estrogen Receptor, Progesterone Receptor, Her 2 Neu Receptor.
References
- Yersal O, Barutca S. Biological subtypes of breast cancer: Prognostic and therapeutic implications. World J Clin Oncol.2014; 5(3): 412-424.
- Diversity of Breast Carcinoma: Histological Subtypes and Clinical Relevance. Clinical Medicine Insights. Pathology.2015;8 :23–31.
- Rajpal S, Kumar A, Joe W. Economic burden of cancer in India: Evidence from cross-sectional nationally representative household survey- 2014. PLoS ONE .2018;13(2):1-17.
- Thiygarajan M, Navrathan N, Mohanapriya T, Kumar A, Singh B. Correlation between estrogen receptor, progesterone receptor, HER-2/neu and other prognostic factors in carcinoma breast in Indian population. Int Surg J. 2015; 2:515-22.
- Gupta D, Gupta V, Marwah N, Gill M, Gupta S, Gupta G et al.Correlation of Hormone Receptor Expression with Histologic Parameters in benign and malignant breast tumors. Iranian Journal of Pathology.2015;10 (1): 23 – 34.
- Omranipour R , Alipour S , Hadji M , Fereidooni F, Jahanzad I, Bagheri K. Accuracy of Estrogen and Progesterone Receptor Assessment in Core Needle Biopsy Specimens of Breast Cancer. IRCMJ. 2013 June; 15(6): 515-8.
- Louie M.C, Sevigny M.B. Steroid hormone receptors as prognostic markers in breast cancer. Am J Cancer Res .2017;7(8):1617-1636.
- Geethamala K et al. Histopathological Grade versus Hormone Receptor Status in Breast Carcinoma- Treasure The Past. International Journal of Biomedical Research .2015; 6(07): 466-471.
- Pakseresht S, Ingle G K, Bahadur A K, Ramteke V K, Singh M M, Garg S, Agarwal P N. Risk factors with breast cancer among women in Delhi. Indian J Cancer. 2009; 46:132-8.
- Azizun-Nisa, Bhurgri Y, Raza F, Kayani N. Comparison of ER, PR and HER-2/neu (C-erb B 2) reactivity pattern with histologic grade, tumor size and lymph node status in breast cancer. Asian Pac J Cancer Prev .2008; 9:553-6.
- Suvarchala SB, Nageshwararao R. Carcinoma Breast-Histopathological and hormone receptors correlation. J Biosci Tech.2011:2; 340-48.
- Ghosh J, Gupta S, Desai S, Shet T, Radhakrishnan S, Suryavanshi P et al. Estrogen, progesterone and HER2 receptor expression in breast tumors of patients, and their usage of HER2-targeted therapy, in a tertiary care centre in India. Indian J Cance. 2011;48:391-6
- Ambroise M, Ghosh M, Mallikarjuna VS, Kurian A. Immunohistochemical Profile of Breast Cancer Patients at a Tertiary Care Hospital in South India Immunohistochemical Profile of Breast Cancer Patients at a Tertiary Care Hospital in South India. Asian Pacific Journal of Cancer Prevention. 2011;12:625-629.
- Shet T, Agrawal A, Nadkarni M, Palkar M, Havaldar R, Parmar V, et al. Hormone receptors over the last 8 years in a cancer referral centre in India: What was and what is. Indian J Pathol Microbiol.2009; 50:284-90.
- Murthy N S, Chaudhry K, Nadayil D, Agarwal U K, Saxena S. Changing trends in incidence of breast cancer: Indian scenario. Indian J Cancer.2009; 46:73.
- Nandakumar A, Ramnath T, Chaturvedi M. The magnitude of cancer breast in India: a summary. Indian J Surg Oncol. 2010; 1:8-9.
- Rhodes A, Jasani B, Balaton AJ, Barnes DM, Miller KD. Frequency of oestrogen and progesterone receptor positivity by immunohistochemical analysis in 7016 breast carcinomas: correlation with patient age, assay sensitivity, threshold value, and mammographic screening. J Clin Pathol. 2000; 53: 688-96.
- Sandhu DS, Sandhu S, Karwasra RK, Marwah S. Profile of breast cancer patients at a tertiary care hospital in north India. Indian J Cancer .2010; 47:16-22.
- Lokuhetty MDS, Ranaweera GG, Wijeratne MD, Sheriffdeen SH. Profile of breast cancer in a group of women in a developing country in South Asia: is there a difference? World J Surg. 2009 Mar;33(3):455-9.
- Lakmini KB. Mudduwa. Quick score of hormone receptor status of breast carcinoma: correlation with the other clinico-pathological prognostic parameters. Indian J Pathol Microbiol. 2009; 52:159-63.
- Puvitha R D, S Shifa. Breast Carcinoma, Receptor Status, and Her2 neu Overexpression Revisited. International Journal of Scientific Study, 2016 Jan;3(10); 52-58.
- Sofi GN, Nabi J, Nadeem R, Shiekh RY, Khan FA, Sofi AA, et al. Estrogen receptor and progesterone receptor status in breast cancer in relation to age, histological grade, size of lesion and lymph node involvement. Asian Pacific J Cancer Prev 2012;13:5047-5052.
- Lobna Ayadi, Abdelmajid Khabir, Habib Amouri, Sondes Karray, Abdallah Dammak, Mohamed Guermazi, et al. Correlation of HER-2 overexpression with clinico-pathological parameters in Tunisian breast carcinoma. World J Surg Oncol. 2008;6:112.
- Zubair Ahmad, Amna Khurshid, Asim Qureshi, Romana Idress, Nasira Asghar, Naila Kayani. Breast carcinoma grading, estimation of tumor size, axillary lymph node status, staging, and Nottingham prognostic index scoring on mastectomy specimens. Indian J Pathol Microbiol. 2009;52:477-81.
- Pathak TB, Bashyal R, Pun CB, Shreastha S, Bastola S, Neupane S, et al. Estrogen and Progesterone receptor expression in breast carcinoma. Journal of Pathology of Nepal 2011;1:100-103.
- Desai SB, Moonim MT, Gill AK, Punia RS, Naresh KN, Chinoy RF et al. Hormone receptor status of breast cancer in India: a study of 798 tumours. The Breast. 2000 Oct; 9(5):267-70.
- Priti Lal, Lee K. Tan, Beiyun Chen. Correlation of HER2 Status with Estrogen and Progesterone Receptors and Histologic Features in 3,655 Invasive Breast Carcinomas. Am J Clin Pathol . 2005;123:541-46.
- Rao C, Shetty J, Prasad HL. Study of morphological profile and receptor status in breast carcinoma. Journal of Cancer Research and Therapeutics . 201;:9(1):44-49.
- Dutta V, Chopra GS, Sahai K, Nema SK. Hormone Receptors, Her-2/Neu and chromosomal Aberrations in Breast Cancer. MJAFI. 2008;64:11-15.
- Thike AA, Cheok PY, Jara-Lazaro AR, Tan B, Tan P, Tan PH. Triple-negative breast cancer: clinicopathological characteristics and relationship with basal-like breast cancer. Mod Pathol. 2010 Jan;23(1):123-33.
Corresponding Author
Dr Anup Kumar
Department of Pathology, RDBP Jaipuria Hospital, Jaipur, Rajasthan, India
DOI: https://dx.doi.org/10.18535/jmscr/v8i1.86
