Abstract
Background: Lung cancer is the commonest cancer worldwide. The prevalence is increasing in women. There is also a changing trend in histology with increase in adenocarcinoma type.
Material and Methods: This is a retrospective analysis of 200 cases with lung cancer who were registered in the Department of Radiation Oncology, RIMS, Manipur, India from January 2011 to August 2019.
Result: Majority of the patients were in age group of 61-70 years (37.57%). 68.0% of the patients presented with stage IV disease. Majority of our patients belong to class III socio-economic status (56.0%).
Squamous cell type was the commonest histopathology (42.14%) followed by adenocarcinoma, small cell lung cancer (SCLC) and undifferentiated type accounting for 34.59%, 11.95% and 11.32% respectively
Out of 200 patients, 67.50% were smokers and 12.50% were passive smokers,152 patients (76.0%) had history of exposure to smoky house from combustion of solid fuels for cooking and 97 patients (48.50%) were exposed to dust.
Cough was the commonest symptom (66.50%) followed by shortness of breath (60.50%) and chest pain (48.50%). On radiological evaluation, mass lesion was the commonest finding (52.0%) followed by mass with effusion (22.5%), mass with effusion and collapse (14.5%) respectively and mass with consolidation was present in 11.0% of the study population. And right sided lung mass was more common (65.0%) compared to left (35.0%).
Out of 200 patients 76 (38.0%) presented with distant metastasis. Contra lateral lung was the commonest site of metastasis (17.0%) followed by bone (13.50%), brain (12.50%), liver (10.0%) and adrenal (1.5%).
Conclusion: Lung cancer contributes a major disease burden to women in Manipur. The present study highlighted the urgent need of population based awareness program of lung cancer in Manipur for prevention and early detection of lung cancer.
References
- Kamangar F, Dores GM, Anderson WF. Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol. 2006;24 (14):2137–50.
- Takiar R, Nadayil D, Nandakumar A. Projections of number of cancer cases in India (2010-2020) by cancer groups. Asian Pac J Cancer 2010;11(4):1045-9.
- Silvestri GA, Pastis NJ, Tanner NT, Jett JR. Clinical Aspect of Lung cancer. In: Broaddus VC, editor-in-chief. Murray & Nadel’s Textbook of Respiratory Medicine, 6th ed. Delhi: Elsevier; 2017.p.940-64.
- Brennan P, Buffler PA, Reynolds P, Wu AH, Wichmann HE, Agudo A, et al. Secondhand smoke exposure in adulthood and risk of lung cancer among never smokers: A pooled analysis of two large studies. Int J Cancer 2004;109(1):125-31.
- Vineis P, Airoldi L, Veglia F, Olgiati L, Pastorelli R, Autrup H, et al. Environment tobacco smoke and risk of respiratory cancer and chronic obstructive pulmonary disease in former smokers and never smokers in the EPIC prospective study.BMJ 2005;330(7486):277.
- Darby S, Hill D, Auvinen A, Barros- Dios JM, Baysson H, Bochicchio F, et al. Radon in homes and risk of lung cancer: Collaborative analysis of individual data from 13 European case control studies. BMJ 2005;330(7485):223.
- Park J, Kim DS, Shim TS, Lim CM, Koh Y, Lee SD, et al. Lung cancer in patients with idiopathic pulmonary fibrosis. Eur Respir J 2001;17:1216–19.
- Gupta RC, Purohit SD, Sharma MP, Bhardwaj S. Primary bronchogenic carcinoma: Clinical profile of 279 cases from mid- west Rajasthan. Indian J Chest Dis Allied Sci 1998;40(2):109-16.
- Wu AH, Yu MC, Thomas DC, Pike MC. Personal and family history of lung disease as a risk factor for adenocarcinoma of lung. Cancer Res 1988;48(24 Pt1):7279-84.
- Jemal A, Ward E, Thun MJ. Contemporary lung cancer trends among US women. Cancer Epidemiology Biomarkers Prev 2005;14(3):582-85
- Brian LE, Sibele IM, Douglas BF, Margie LC. Population- based trends in lung cancer incidence in women. Semin Oncol 2009;36(6):506–515.
- Subhankar C, Apar KG, Allisa M, Surinder KB. Lung cancer in women: role of estrogen. Expert Rev Respir Med 2010;4(4):509–518.
- Sundaram V, Sanjay N. Clinicopatho-logical profile of bronchogenic carcinoma in a tertiary care hospital in eastern part of India. Clin Cancer Inv J 2014;3:220-4.
- Agrawal A, Agrawal PK, Tandon R, Singh S, Singh L, Sharma S. Pulmonary tuberculosis as a confounder for bronchogenic carcinoma due to delayed and misdiagnosis. Ind J Comm Health 2013;25:(4)438-44.
- Hammond EC, Horn D. Smoking and death rates: Report on 44 months of follow up of 187, 783 men. II. Death rates by cause. J Am Med Assoc 1958;166(11): 1294-308.
- Zhong L, Goldberg MS, Parent ME, Hanley JA. Exposure to environmental tobacco smoke and the risk of lung cancer: a meta-analysis. Lung Cancer 2000; 27(1):3-18.
- Rapiti E, Jindal SK, Gupta D, Boffetta P. Passive smoking and lung cancer in Chandigarh, India. Lung Cancer 1999;23(3):183-9.
- Kumar M, Sharma DK, Garg M, Jain P. Clinico-pathological profile of lung cancer – Changing trend in India. Int J Res Med 2016;5(2)57-62.
- Mohan A, Latifi AN, Guleria R. Increasing incidence of adenocarcinoma lung in India: Following the global trend? Indian J Cancer 2016;53(1):92-5.
- Malik AK, Aikat BK. Primary pulmonary Neoplasm: A Histopathological study. Indian J Cancer 1976; 13:149-55.
- Jagadish R, Girish S, Dushyant G, Ruchi D, Sunil S. Clinico- pathological profile of lung cancer in Uttarakhand. Lung India 2009;26(3):74-6.
- Sheikh S, Shah A, Arshed A, Ahmad R, Rumana M. Histological pattern of primary malignant lung tumours diagnosed in a tertiary care hospital: 10 year study. Asian Pac J Cancer Prev 2010;11(5):1341-6.
- Radzikowska E, Glaz P, Roszkowski K. Lung cancer in women:age, smoking, histology, performance status, stage, initial treatment and survival. Population based study of 20561 cases. Ann Oncol 2002;13(7):1087-93.
Corresponding Author
Dr C. Lalrindiki
Post Graduate Trainee